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REVIEW article

Front. Physiol.
Sec. Renal Physiology and Pathophysiology
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1490725

Signal pathways involved in contrast-induced acute kidney injury

Provisionally accepted
Ke Deng Ke Deng Mingxin Pei Mingxin Pei Beibei Li Beibei Li Nanqi Yang Nanqi Yang Zijian Wang Zijian Wang Xinchi Wan Xinchi Wan Zhiying Zhong Zhiying Zhong Zhiyi Yang Zhiyi Yang Yanling Chen Yanling Chen *
  • Department of Pathophysiology, Zhuhai Campus of Zunyi Medical University,, Zhuhai, China

The final, formatted version of the article will be published soon.

    Contrast-induced acute kidney injury (CI-AKI) has emerged as a global public health concern, ranking as the third most prevalent cause of hospital-acquired acute kidney injury, which is related to adverse outcomes. However, its precise pathogenesis remains elusive. Consequently, researchers are dedicated to uncovering CI-AKI's pathophysiology and signaling pathways, including inflammation, oxidative stress, apoptosis, and ferroptosis, to improve prevention and treatment. This review thoroughly analyzes the signaling pathways and their interactions associated with CI-AKI, assesses the impact of various research models on pathway analysis, and explores more precise targeted treatment and prevention approaches. Aims to furnish a robust theoretical foundation for the molecular mechanisms underpinning clinical treatments.

    Keywords: Contrast-induced acute kidney injury, Signal pathways, Oxidative Stress, Inflammatory, Apoptosis, ferroptosis

    Received: 03 Sep 2024; Accepted: 12 Nov 2024.

    Copyright: © 2024 Deng, Pei, Li, Yang, Wang, Wan, Zhong, Yang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yanling Chen, Department of Pathophysiology, Zhuhai Campus of Zunyi Medical University,, Zhuhai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.