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REVIEW article

Front. Physiol.
Sec. Cardiac Electrophysiology
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1473501

Research Progress of Two-pore Potassium Channel in Myocardial Ischemia-reperfusion Injury

Provisionally accepted
Yue Zhang Yue Zhang Jing Li Jing Li *Shengli Deng Shengli Deng *
  • Affiliated Hospital of Zunyi Medical University, Zunyi, China

The final, formatted version of the article will be published soon.

    Myocardial ischemia-reperfusion injury (MIRI) is a secondary injury caused by restoring blood flow after acute myocardial infarction, which may lead to serious arrhythmia and heart damage. In recent years, the role of potassium channels in MIRI has attracted much attention, especially the members of the two-pore domain potassium (K2P) channel family. K2P channel has unique structure and function, and the formation of its heterodimer increases its functional diversity. This paper reviews the structural characteristics, types, expression and physiological functions of K2P channel in the heart. In particular, we pay attention to whether members of the subfamily such as TWIK, TREK, TASK, TALK, THIK and TRESK participate in MIRI and their related mechanisms. Future research will help to reveal the molecular mechanism of K2P channel in MIRI and provide new strategies for the treatment of cardiovascular diseases.

    Keywords: Two-pore potassium channel, K2P channel, KCNK, cardiovascular disease, Myocardial ischemia-reperfusion injury

    Received: 31 Jul 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Zhang, Li and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jing Li, Affiliated Hospital of Zunyi Medical University, Zunyi, China
    Shengli Deng, Affiliated Hospital of Zunyi Medical University, Zunyi, China

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