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ORIGINAL RESEARCH article

Front. Physiol.
Sec. Developmental Physiology
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1442000

Nonlinear pathological trajectory of a high-myopia C57/BL6J mouse model induced by form deprivation

Provisionally accepted
Yue Wen Yue Wen Yan Li Yan Li Li Zhu Li Zhu Tao Tang Tao Tang Huichao Yan Huichao Yan Jie Hu Jie Hu Kai Wang Kai Wang Zhao Mingwei Zhao Mingwei *Qiong Xu Qiong Xu *
  • Peking University People's Hospital, Beijing, China

The final, formatted version of the article will be published soon.

    To establish a high myopia model in C57BL/6J mice with monocular form deprivation myopia (FDM) and investigate its ocular structure pathological trajectory. Healthy 3-week-old C57BL/6J mice were divided into an FDM group (n = 36) and a control group (n = 24). The left eyes of the FDM group were patched, while the right eyes served as controls. Biometric parameters and fundus morphology were assessed at baseline and after 4, 8, and 12 weeks of form deprivation. Significant differences were observed in the deprived eyes, including longer axial length, higher refractive power, deeper vitreous chambers, thinner retina, choroid, and sclera, and smaller scleral fibers’ diameters under a transmission electron microscope. Retinal vascular area proportion in covered eyes decreased significantly (P < 0.05), with a decline rate of 11% from weeks 4 to 8 and a faster decline of 19% from weeks 8 to 12, while this proportion increased significantly in control eyes. This study successfully induced a high myopia model in mice with long-term form deprivation. The axial length grew dramatically in FDM in the first 8 weeks, while the pathological progress of the fundus accelerated from weeks 8 to 12.

    Keywords: Form deprivation myopia, High myopia, retinal vessel, Choroidal thickness, scleral fiber, nonlinear pathological trajectory

    Received: 01 Jun 2024; Accepted: 18 Oct 2024.

    Copyright: © 2024 Wen, Li, Zhu, Tang, Yan, Hu, Wang, Mingwei and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhao Mingwei, Peking University People's Hospital, Beijing, China
    Qiong Xu, Peking University People's Hospital, Beijing, China

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