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ORIGINAL RESEARCH article

Front. Physiol.
Sec. Integrative Physiology
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1440307
This article is part of the Research Topic Crosstalk between lung and brain, heart, kidney and vascular system in critical illness View all 5 articles

Clinical implication of electrocardiogram change in patients experiencing lung transplantation with end stage lung disease

Provisionally accepted
Ah Young Leem Ah Young Leem 1Hee Tae Yu Hee Tae Yu 1MinDong Sung MinDong Sung 1Kyung Soo Chung Kyung Soo Chung 1Yeonkyeong Kim Yeonkyeong Kim 1Al Woo Al Woo 1Song Yee Kim Song Yee Kim 1Moo Suk Park Moo Suk Park 1YOUNG SAM KIM YOUNG SAM KIM 1Young Ho Yang Young Ho Yang 1Ha Eun Kim Ha Eun Kim 1Jin Gu Lee Jin Gu Lee 1Kyuseok Kim Kyuseok Kim 2Kyu Bom Kim Kyu Bom Kim 3Boyoung Joung Boyoung Joung 1Junbeom Park Junbeom Park 4*Su Hwan Lee Su Hwan Lee 1*
  • 1 College of Medicine, Yonsei University, Seoul, Republic of Korea
  • 2 Eulji University, Daejeon, Daejeon, Republic of Korea
  • 3 Yonsei University, Seoul, Seoul, Republic of Korea
  • 4 Ewha Womans University, Seoul, Seoul, Republic of Korea

The final, formatted version of the article will be published soon.

    Introduction: End-stage lung disease causes cardiac remodeling and induces electrocardiogram (ECG) changes.On the other way, whether lung transplantation (LTx) in end-stage lung disease patients are associated with ECG change is unknown. The object of this study was to investigate ECG changes before and after LTx in end-stage lung disease patients and whether these changes had clinical significance.This was a single-center retrospective cohort study of 280 end-stage lung disease patients who consecutively underwent LTx at a tertiary referral hospital. ECG findings before LTx and within 1 week and 1, 3, and 6 months after LTx were obtained and analyzed. To find clinical meaning, the ECG at 1 month after LTx was analyzed according to 1-year survival (survivor vs. non-survivor groups). Survival data were estimated using the Kaplan-Meier method.Results: Significant differences were observed in the PR interval, QRS duration, QT interval, QTc interval, and heart rate before LTx and 1 month after LTx; the PR interval, QRS duration, QTc interval, and heart rate were decreased. Particularly, the QTc interval was significantly decreased 1 month after LTx, whereas there was no significant change in the QTc interval from 1 to 6 months thereafter. The PR interval, QT interval, QTc interval, and heart rate were significantly different between the survivor and non-survivor groups. The serial changes in QTc interval before LTx and 1 and 3 months after LTx were also significantly different between the survivor and non-survivor groups (P=0.040 after adjusting for age and body mass index). Upon dividing the patients based on the range of QTc interval change ≤-8ms, >-8-10ms, >10-35ms, >35ms), the survival rate was significantly lower in the group whose QTc interval at 1 month after LTx decreased by >35ms (P=0.019).LTx in patients with end-stage lung disease may induce ECG changes. Patients whose QTc interval at 1 month after LTx decreased by >35ms have a significantly higher 1-year mortality rate. Hence, these ECG changes may have clinical and prognostic significance.

    Keywords: electrocardiogram, end-stage lung disease, Lung Transplantation, risk factor, prognosis

    Received: 08 Jun 2024; Accepted: 14 Oct 2024.

    Copyright: © 2024 Leem, Yu, Sung, Chung, Kim, Woo, Kim, Park, KIM, Yang, Kim, Lee, Kim, Kim, Joung, Park and Lee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Junbeom Park, Ewha Womans University, Seoul, 120-750, Seoul, Republic of Korea
    Su Hwan Lee, College of Medicine, Yonsei University, Seoul, Republic of Korea

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