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MINI REVIEW article

Front. Physiol.
Sec. Chronobiology
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1435848

Effect of circadian clock disruption on type 2 diabetes

Provisionally accepted
Hong Thuan Tran Hong Thuan Tran 1Takeru Kondo Takeru Kondo 2*Amal A. Mohamed Amal A. Mohamed 2Fu Yunyu Fu Yunyu 2Hiroko Okawa Hiroko Okawa 2Hiroshi Egusa Hiroshi Egusa 2*
  • 1 Ho Chi Minh City University of Science, Ho Chi Minh City, Vietnam
  • 2 Tohoku University, Sendai, Japan

The final, formatted version of the article will be published soon.

    Introduction: Type 2 diabetes (T2D) is the predominant form of diabetes mellitus and is among the leading causes of death with an increasing prevalence worldwide. However, the pathological mechanism underlying T2D remains complex and unclear. An increasing number of studies have suggested an association between circadian clock disruption and high T2D prevalence. Method: This review explores the physiological and genetic evidence underlying T2D symptoms associated with circadian clock disturbances, including insulin secretion and glucose metabolism. Results and Discussion: Notably, circadian clock disruption reduces insulin secretion and insulin sensitivity and negatively affects glucose homeostasis. The circadian clock regulates the hypothalamic-pituitaryadrenal axis, an important factor that regulates glucose metabolism and influences T2D progression. Therefore, circadian clock regulation is an attractive, novel therapeutic approach for T2D, and various circadian clock stabilizers play therapeutic roles in T2D. Lastly, this review suggests novel therapeutic and preventive approaches using circadian clock regulators for T2D.

    Keywords: type 2 diabetes, Circadian clock, insulin secretion, Insulin Resistance, glucose metabolism, HPA axis

    Received: 21 May 2024; Accepted: 08 Jul 2024.

    Copyright: © 2024 Tran, Kondo, Mohamed, Yunyu, Okawa and Egusa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Takeru Kondo, Tohoku University, Sendai, Japan
    Hiroshi Egusa, Tohoku University, Sendai, Japan

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.