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SYSTEMATIC REVIEW article

Front. Physiol.
Sec. Exercise Physiology
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1428723

Comparative efficacy of difference exercise modalities on metabolic profiles and liver functions in non-alcoholic fatty liver disease: A network meta-analysis

Provisionally accepted
Mingming Huang Mingming Huang 1Jiafa Yang Jiafa Yang 2Yihao Wang Yihao Wang 1*Jian Wu Jian Wu 1*
  • 1 Capital Institute of Physical Education and Sports, Beijing, Beijing, China
  • 2 Dong-A University, Busan, Republic of Korea

The final, formatted version of the article will be published soon.

    Research evidence suggests that exercise is a potent therapeutic strategy for non-alcoholic fatty liver disease (NAFLD). Many investigations have delved into the curative potential of diverse exercise regimens on NAFLD. This investigation synthesizes findings from randomized controlled trials via a network meta-analysis to evaluate the efficacy of exercise-based interventions on NAFLD.We conducted a search across five electronic databases(Web of Science, EMBASE, PubMed, SCOPUS, and CNKI)to identify randomized controlled trials (RCTs) comparing the effects of different exercise modalities on metabolic profiles and liver functions in patients with NAFLD. The literature search was comprehensive up to December 15, 2023. The selected studies were subjected to a rigorous quality appraisal and risk of bias analysis in accordance with the Cochrane Handbook's guidelines, version 5.1.0. We employed Stata/MP 17 for the network meta-analysis, presenting effect sizes as standardized mean differences (SMD).Results: This study aggregated results from 28 studies, involving a total of 1,606 participants. The network meta-analysis revealed that aerobic exercise was the most effective intervention for improving BMI in patients with NAFLD, demonstrating a significant decrease in BMI (-0.72, 95%CI: -0.98 to -0.46; P < 0.05; Surface Under the Cumulative Ranking (SUCRA) = 79.8%). HIIT was the top intervention for enhancing HDL-C (0.12, 95% CI: 0.04 to 0.20; P < 0.05; SUCRA = 76.1%).Resistance exercise was the most effective for reducing LDL-C (-0.20, 95% CI: -0.33 to -0.06; P < 0.05; SUCRA = 69.7%). Mind-body exercise showed superior effectiveness in improving TC (-0.67, 95%

    Keywords: nonalcoholic fatty liver disease, Exercise, Network meta-analysis, Aerobic, physical activity

    Received: 06 May 2024; Accepted: 28 Aug 2024.

    Copyright: © 2024 Huang, Yang, Wang and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yihao Wang, Capital Institute of Physical Education and Sports, Beijing, 100088, Beijing, China
    Jian Wu, Capital Institute of Physical Education and Sports, Beijing, 100088, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.