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ORIGINAL RESEARCH article

Front. Physiol.
Sec. Exercise Physiology
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1428404

Single and consecutive 10-Day Remote Ischemic Preconditioning Modify Physical Performance, Post-Exercise Exerkine Levels, and Inflammation

Provisionally accepted
Magdalena Kochanowicz Magdalena Kochanowicz 1Paulina Brzezinska Paulina Brzezinska 2Jan Mieszkowski Jan Mieszkowski 2Andrzej Kochanowicz Andrzej Kochanowicz 2Bartlomiej Niespodzinski Bartlomiej Niespodzinski 3Marcin Surmiak Marcin Surmiak 4Joanna Reczkowicz Joanna Reczkowicz 1Andzelika Borkowska Andzelika Borkowska 1Jedrzej Antosiewicz Jedrzej Antosiewicz 1*
  • 1 Medical University of Gdansk, Gdańsk, Poland
  • 2 Gdansk University of Physical Education and Sport, Gdańsk, Pomeranian, Poland
  • 3 Kazimierz Wielki University of Bydgoszcz, Bydgoszcz, Pomeranian, Poland
  • 4 Jagiellonian University Medical College, Kraków, Lesser Poland, Poland

The final, formatted version of the article will be published soon.

    Purpose: Remote ischemic preconditioning (RIPC) is a method of protection against induced ischemia reperfusion injury, and an increasing number of studies showed some of its inconclusive ergogenic effects in sports. RIPC involves short cycles of cuff inflation followed by its deflation which may affect many body systems. While most of the studies focus on single RIPC effects, there is insufficient data regarding training-like repeated RIPC interventions.Thus, in this study, we analyzed the effect of a single-and consecutive 10-day RIPC procedure on a single leg, focusing on the exerkine levels and changes in inflammation markers following the Wingate Anaerobic Test (WAnT).Methods: Two single-blinded, sham-controlled protocols were designed to evaluate the 1) single (crossover study) and 2) consecutive 10-day (parallel study) RIPC effects on the WAnT performance and exercise-induced lactate, glucose, exerkine, and inflammation markers (BDNF; IL-6; IL-10; IL-15; LIF; oncostatin M). In each protocol, 37 physically active men (19.98 ± 1.17 years) were randomly assigned into two groups according to a particular study design.Results: An increase in participants' mean (4.81%, p < 0.05) and peak power (6.25%, p < 0.05) during the WAnT was observed only after the consecutive 10-day RIPC. Similarly, a significant 15.5% (p < 0.05) decrease in the IL-6 concentration 120 minutes after the WAnT was observed -usunięto: ¶ -usunięto: that only in the consecutive 10-day RIPC protocol, as well as a 12.2% (p < 0.01) increase in oncostatin M 60 minutes after the WAnT.The results demonstrate the efficacy of the consecutive 10-day RIPC procedure in modulating exercise performance and post-exercise inflammation markers.

    Keywords: endurance exercise, Ischemic preconditioning (IPC), Skeletal muscle damage, Inflammation, Wingate anaerobic performance

    Received: 06 May 2024; Accepted: 23 Oct 2024.

    Copyright: © 2024 Kochanowicz, Brzezinska, Mieszkowski, Kochanowicz, Niespodzinski, Surmiak, Reczkowicz, Borkowska and Antosiewicz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jedrzej Antosiewicz, Medical University of Gdansk, Gdańsk, Poland

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