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CASE REPORT article

Front. Physiol.
Sec. Exercise Physiology
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1404657
This article is part of the Research Topic Precision Exercise Prescription: Data-Driven Strategies for Neuromuscular and Cardiovascular Training Across Athletes, Healthy Individuals and Chronic Disease Populations View all articles

Case Report: A Creatine Kinase-Borg Scale Values-Based Approach to Tailor Physical Training in a Central Core Myopathy Patient

Provisionally accepted
Oscar Crisafulli Oscar Crisafulli 1Jessica Lacetera Jessica Lacetera 1Giorgio Bottoni Giorgio Bottoni 1Angela Berardinelli Angela Berardinelli 2Luca Grattarola Luca Grattarola 1Martina Veltroni Martina Veltroni 1Stefano Acquadro Stefano Acquadro 1Massimo Negro Massimo Negro 1Emanuela Lavaselli Emanuela Lavaselli 1Giuseppe D'Antona Giuseppe D'Antona 1*
  • 1 University of Pavia, Pavia, Italy
  • 2 Neurological Institute Foundation Casimiro Mondino (IRCCS), Pavia, Lombardy, Italy

The final, formatted version of the article will be published soon.

    Background: Patients with central core myopathy (CCM) can be at risk of exercise-induced rhabdomyolysis and myalgia. Despite its possible positive effects, physical training has been long avoided in these patients as no population-specific exercise adaption strategies have been developed. Here we present the case of a 17-yearold male CCM patient who underwent a 3-month training program tailored to a preliminary test aimed at assessing his physical exertion tolerance measured via changes in serum creatine kinase (CK). The preliminary tolerance test consisted of three 25-minutes sessions (one session per week) of physical exercise (aerobic,resistance and mixed) at an intensity quantified as level 6 of the Borg Category Ratio (CR) 0-10 scale. A blood sample to assess CK was conducted 36 hours following each session. The intervention consisted of a training program (three sessions per week) including both resistance and aerobic exercises concomitant with a personalized nutritional plan. Before and after intervention, a battery of metabolic (indirect calorimetry,bioimpedance) and cardiopulmonary (CPET) tests were performed. Results: After training, improvements of the anaerobic threshold (+6.9%), normalized VO2 max (+15%) and body composition (muscle mass, +1.1 kg;fat mass, -1.1 kg) were observed without pain, rhabdomyolysis, and blood CK augmentation compared to pretraining values. Conclusions: Our results highlight that a mixed aerobic/resistance training, properly tailored and supported by a specific nutritional plan, may safely improve the physical fitness and body composition in a CCM patient. Dosing exercise-induced CK serum change following Borg CR-10 intensity assessment, may be useful to correctly tailor physical exercise in these patients.

    Keywords: neuromuscular disorder, Creatine Kinase, Exercise tailoring, Resistance Training, aerobic training

    Received: 21 Mar 2024; Accepted: 03 Jul 2024.

    Copyright: © 2024 Crisafulli, Lacetera, Bottoni, Berardinelli, Grattarola, Veltroni, Acquadro, Negro, Lavaselli and D'Antona. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Giuseppe D'Antona, University of Pavia, Pavia, Italy

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