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ORIGINAL RESEARCH article

Front. Physiol.
Sec. Lipid and Fatty Acid Research
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1398793

Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and hypertension in American adults: A NHANES cross-sectional study

Provisionally accepted
Jiabei Wu Jiabei Wu 1,2*Jinli Guo Jinli Guo 1,2
  • 1 Department of Nursing, Second Hospital of Shanxi Medical University, Taiyuan, China
  • 2 School of Nursing, Shanxi Medical University, Taiyuan, China

The final, formatted version of the article will be published soon.

    Objectives: The relationship between non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol ratio (NHHR) and hypertension remains uncertain, warranting further investigation. This study aims to elucidate the association between NHHR and hypertension. Methods: A comprehensive cross-sectional stratified survey involving 30,602 participants aged 20 years and older was conducted using the National Health and Nutrition Examination Survey (NHANES) dataset from 2001 to 2018. NHHR was calculated as (total cholesterol (TC) - high-density lipoprotein cholesterol (HDL-C))/HDL-C. The relationship between NHHR and hypertension was examined using weighted multiple linear regression, smooth curve fitting, hierarchical analysis, and interaction testing. Results: The mean age of participants was 49.82±17.64 years, with 15,266 women included. The average NHHR was 2.94±0.56. A positive correlation between NHHR and hypertension was observed. Stratification of NHHR into quartiles, in the fully adjusted Model 3, revealed that individuals in the highest NHHR quartile had a 60% increased risk of hypertension for each unit increase in NHHR compared to those in the lowest quartile. Interaction tests indicated that the relationship between NHHR and hypertension remained consistent across subgroups, except for gender, age, education, and smoking status, which influenced this association. Conclusions: Analysis of NHANES data from 2001 to 2018 demonstrated a consistent positive association between NHHR and hypertension. NHHR may provide potential assistance in hypertension prevention and diagnosis.

    Keywords: Lipid ratio, Non-HDL-C/HDL-C (NHHR), NHANES, Hypertension, Cross-sectional study

    Received: 25 Jun 2024; Accepted: 31 Jul 2024.

    Copyright: © 2024 Wu and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jiabei Wu, Department of Nursing, Second Hospital of Shanxi Medical University, Taiyuan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.