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REVIEW article

Front. Physiol.
Sec. Respiratory Physiology and Pathophysiology
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1394633

Pyroptosis in Macrophages: Bridging Acute Respiratory Distress Syndrome (ARDS) and Pulmonary Fibrosis (PF) Progression

Provisionally accepted
Jinfeng Liao Jinfeng Liao 1Qin Xie Qin Xie 2Mingjun Yao Mingjun Yao 3Jin-Ming Zhang Jin-Ming Zhang 4Zhengteng Yang Zhengteng Yang 5Si-Yuan Song Si-Yuan Song 6Yi Wang Yi Wang 1*
  • 1 Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China
  • 2 Zhongnan Hospital, Wuhan University, Wuhan, Hubei Province, China
  • 3 University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China
  • 4 Beijing Friendship Hospital, Capital Medical University, Beijing, Beijing Municipality, China
  • 5 Guangxi University of Chinese Medicine, Nanning, Guangx, China
  • 6 Baylor College of Medicine, Houston, Texas, United States

The final, formatted version of the article will be published soon.

    Acute respiratory distress syndrome (ARDS) and pulmonary fibrosis (PF) represent critical stages in the continuum of lung disease progression, where inflammation and fibrosis play pivotal roles. Recent insights into the pathogenesis of these conditions have highlighted the significance of pyroptosis, a form of programmed cell death characterized by gasdermin-mediated membrane pore formation and subsequent cell lysis. This review delves into the mechanistic pathways of pyroptosis in macrophages and its consequential role in the exacerbation of ARDS and its progression to PF. We explore the canonical and non-canonical inflammasome pathways that mediate pyroptosis, emphasizing the role of gasdermins and cytokines in this process. Furthermore, we discuss the dual nature of pyroptosis in host defense and disease progression, underscoring the potential of targeting pyroptotic pathways as a therapeutic strategy for managing ARDS and preventing its progression to PF. By understanding the intricacies of pyroptosis in macrophages, we aim to shed light on novel interventions that could mitigate inflammation and fibrosis, offering new hope for patients suffering from these debilitating lung diseases.

    Keywords: pyroptosis, Macrophages, Acute Respiratory Distress Syndrome, Pulmonary Fibrosis, Inflammasome, gasdermin, Cytokines, Therapeutic Targets ARDS: Acute Respiratory Distress Syndrome

    Received: 05 Apr 2024; Accepted: 25 Nov 2024.

    Copyright: © 2024 Liao, Xie, Yao, Zhang, Yang, Song and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yi Wang, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, 611731, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.