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SYSTEMATIC REVIEW article

Front. Physiol.
Sec. Gastrointestinal Sciences
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1382293

The value of Serum Mac-2 Binding Protein Glycosylation Isomer in the diagnosis of liver fibrosis: A systematic review and meta-analysis

Provisionally accepted
Xinyu Liu Xinyu Liu 1,2Wei Zhang Wei Zhang 3*Baofeng Ma Baofeng Ma 4*Mimi Sun Mimi Sun 5*Qinghua Shang Qinghua Shang 3*
  • 1 Shandong University of Traditional Chinese Medicine, Jinan, China
  • 2 College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
  • 3 Department of Liver Disease, The 960th Hospital of the PLA Joint Logistics Support Force, Jinan, China
  • 4 The third department of encephalopathy, Jinan Integrated Traditional Chinese and Western Medicine Hospital, jinan, China
  • 5 Diagnosis and Treatment Center for Liver Diseases, Tai’an 88 Hospital, tai an, China

The final, formatted version of the article will be published soon.

    The early detection and intervention of liver fibrosis (LF) in patients with chronic liver disease is critical to their management. The accuracy of serum Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) in the diagnosis of LF remains controversial. This study aimed to comprehensively assess the value of serum M2BPGi in diagnosing LF.The PubMed, Embase, MEDLINE, Web of Science, and Cochrane Library databases were searched. The effect values were combined using a random-effects model. Meta-regression and subgroup analysis were used to explore the sources of heterogeneity. In addition, publication bias assessment and sensitivity analysis were conducted.Results: This study includes 12 studies with 2416 patients. The pooled sensitivity, specificity and AUROC of M2BPGi in the diagnosis of significant fibrosis (≥ F2) were 0.65 (95% CI: 0.57-0.71), 0.79 (95% CI: 0.72-0.84) and 0.78(95% CI: 0.74-0.81), respectively, while those for predicting extensive fibrosis (≥ F3) were 0.76 (95% CI: 0.71-0.80), 0.75 (95% CI: 0.68-0.81) and 0.81(95% CI: 0.77-0.84). Sensitivity analysis indicated stable results in this study. The disease type, cut-off values, study country, average age and male proportion were the sources of heterogeneity in diagnosing significant fibrosis of M2BPGi (P < 0.05). And the sample size, disease type, study country, publication year, cut-off values, average age, and male proportion were important sources of heterogeneity in diagnosing extensive fibrosis (P < 0.05).Conclusions: Serum M2BPGi has good diagnostic performance for significant fibrosis and extensive fibrosis in patients with CHB, CHC or NAFLD, and is an effective, non-invasive, and convenient marker.

    Keywords: Mac -2-binding protein glycosylation isomer, liver fibrosis, diagnosis, Meta-analysis, Non-invasive diagnostic index

    Received: 16 Feb 2024; Accepted: 30 Sep 2024.

    Copyright: © 2024 Liu, Zhang, Ma, Sun and Shang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Wei Zhang, Department of Liver Disease, The 960th Hospital of the PLA Joint Logistics Support Force, Jinan, China
    Baofeng Ma, The third department of encephalopathy, Jinan Integrated Traditional Chinese and Western Medicine Hospital, jinan, China
    Mimi Sun, Diagnosis and Treatment Center for Liver Diseases, Tai’an 88 Hospital, tai an, China
    Qinghua Shang, Department of Liver Disease, The 960th Hospital of the PLA Joint Logistics Support Force, Jinan, China

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