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ORIGINAL RESEARCH article

Front. Physiol.
Sec. Exercise Physiology
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1378329
This article is part of the Research Topic Physical Exercise and Diabetes: Exploring the Relationship and Impact on Health Outcome View all 8 articles

A Mendelian randomisation study of the causal effect of exercise intensity on the development of type 2 diabetes

Provisionally accepted
YU FENGLIANG YU FENGLIANG BI HAIXIANG BI HAIXIANG LI SHUNJI LI SHUNJI *
  • Sejong University, Seoul, Republic of Korea

The final, formatted version of the article will be published soon.

    Objective: This study examines the causal effects of varying exercise intensities on type 2 diabetes mellitus (T2D) through Mendelian randomization (MR) analysis, using genetic variants as instrumental variables.Methods: A two-sample MR analysis was performed, employing inverse variance weighting (IVW) as the primary method, supported by weighted median, MR-Egger regression, MR-PRESSO, and MR robustness-adjusted contour scores. Data were obtained from the International Exercise Genetics Database (IEGD) and the Global Diabetes Research Consortium (GRC), encompassing over 150,000 individuals for exercise intensity and around 200,000 T2D patients and controls. SNPs linked to exercise intensity were selected based on genome-wide significance (P < 5×10^-8) and linkage disequilibrium criteria (distance >10,000 kb, r^2 < 0.001).The IVW analysis suggested that high-intensity exercise might reduce T2D risk, but the association was not statistically significant

    Keywords: exercise intensity, type 2 diabetes, Mendelian randomization, causal inference, inverse variance weighted

    Received: 29 Jan 2024; Accepted: 09 Aug 2024.

    Copyright: © 2024 FENGLIANG, HAIXIANG and SHUNJI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: LI SHUNJI, Sejong University, Seoul, Republic of Korea

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