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ORIGINAL RESEARCH article

Front. Physiol.
Sec. Vascular Physiology
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1353768

Quantitative analysis of systemic perfusion and cerebral blood flow in the modeling of aging and orthostatic hypotension

Provisionally accepted
Heming Cheng Heming Cheng *Jifeng Dai Jifeng Dai Gen Li Gen Li Dongfang Ding Dongfang Ding Jianyun Li Jianyun Li Ke Zhang Ke Zhang Liuchuang Wei Liuchuang Wei Jie Hou Jie Hou
  • Kunming University of Science and Technology, Kunming, China

The final, formatted version of the article will be published soon.

    Orthostatic hypotension (OH) is common among the older population. The mechanism hypothesized by OH as a risk factor for cognitive decline and dementia is repeated transient cerebral blood flow deficiency. However, to our knowledge, quantitative evaluation of cardiac output and cerebral blood flow due to acute blood pressure changes resulting from postural changes is rare. We report a new fluid-structure interaction model to analyze the quantitative relationship of cerebral blood flow during OH episodes. A device was designed to simulate the aging of blood vessels. The results showed that OH was associated with decreased transient cerebral blood flow. With the arterial aging, lesions, the reduction in cerebral blood flow is accelerated. These findings suggest that systolic blood pressure regulation is more strongly associated with cerebral blood flow than diastolic blood pressure, and that more severe OH carries a greater risk of dementia. The model containing multiple risk factors could apply to analyze and predict for individual patients. This study could explain the hypothesis that transient cerebral blood flow deficiency in recurrent OH is associated with cognitive decline and dementia.

    Keywords: orthostatic hypotension, cerebral blood flow, Systemic perfusion, Dementia, artery aging

    Received: 11 Dec 2023; Accepted: 22 Jul 2024.

    Copyright: © 2024 Cheng, Dai, Li, Ding, Li, Zhang, Wei and Hou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Heming Cheng, Kunming University of Science and Technology, Kunming, China

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