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REVIEW article

Front. Physiol.
Sec. Vascular Physiology
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1347888
This article is part of the Research Topic Emerging Molecular Mechanisms in Cardiovascular Physiology and Pathology View all 6 articles

Developmental endothelial locus 1: the present and future of an endogenous factor in vessels

Provisionally accepted
DaiSong Jiang DaiSong Jiang Honghua Yue Honghua Yue Wei-Tao Liang Wei-Tao Liang *Zhong Wu Zhong Wu *
  • Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Developmental Endothelial Locus-1 (DEL-1), also known as EGF-like repeat and discoidin I-like domain-3 (EDIL3), is increasingly recognized for its multifaceted roles in immunoregulation and vascular biology. DEL-1 is a protein that is mainly produced by endothelial cells. It interacts with various integrins to regulate the behavior of immune cells, such as preventing unnecessary recruitment and inflammation. DEL-1 also helps in resolving inflammation by promoting efferocytosis, which is the process of clearing apoptotic cells. Its potential as a therapeutic target in immune-mediated blood disorders, cardiovascular diseases, and cancer metastasis has been spotlighted due to its wide-ranging implications in vascular integrity and pathology. However, there are still unanswered questions about DEL-1's precise functions and mechanisms. This review provides a comprehensive examination of DEL-1's activity across different vascular contexts and explores its potential clinical applications. It underscores the need for further research to resolve existing controversies and establish the therapeutic viability of DEL-1 modulation.

    Keywords: Developmental endothelial locus-1, integrin, Inflammation, Efferocytosis, vascular smooth muscle cell Article types

    Received: 01 Dec 2023; Accepted: 25 Jul 2024.

    Copyright: © 2024 Jiang, Yue, Liang and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Wei-Tao Liang, Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
    Zhong Wu, Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.