AUTHOR=Zhang Yu , Cui Jiangbo , Cang Zhengqiang , Pei Jiaomiao , Zhang Xi , Song Baoqiang , Fan Xing , Ma Xianjie , Li Yang 

TITLE=Hair follicle stem cells promote epidermal regeneration under expanded condition

JOURNAL=Frontiers in Physiology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2024.1306011

DOI=10.3389/fphys.2024.1306011

ISSN=1664-042X

ABSTRACT=<p>Skin soft tissue expansion is the process of obtaining excess skin mixed with skin development, wound healing, and mechanical stretching. Previous studies have reported that tissue expansion significantly induces epidermal proliferation throughout the skin. However, the mechanisms underlying epidermal regeneration during skin soft tissue expansion are yet to be clarified. Hair follicle stem cells (HFSCs) have been recognized as a promising approach for epidermal regeneration. This study examines HFSC-related epidermal regeneration mechanisms under expanded condition and proposes a potential method for its cellular and molecular regulation.</p>