AUTHOR=Xie Jun , Yang Yi , Jiang Zekun , Zhang Kerui , Zhang Xiang , Lin Yuheng , Shen Yiwei , Jia Xuehai , Liu Hao , Yang Shaofen , Jiang Yang , Ma Litai 

TITLE=MRI radiomics-based decision support tool for a personalized classification of cervical disc degeneration: a two-center study

JOURNAL=Frontiers in Physiology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1281506

DOI=10.3389/fphys.2023.1281506

ISSN=1664-042X

ABSTRACT=<p><bold>Objectives:</bold> To develop and validate an MRI radiomics-based decision support tool for the automated grading of cervical disc degeneration.</p><p><bold>Methods:</bold> The retrospective study included 2,610 cervical disc samples of 435 patients from two hospitals. The cervical magnetic resonance imaging (MRI) analysis of patients confirmed cervical disc degeneration grades using the Pfirrmann grading system. A training set (1,830 samples of 305 patients) and an independent test set (780 samples of 130 patients) were divided for the construction and validation of the machine learning model, respectively. We provided a fine-tuned MedSAM model for automated cervical disc segmentation. Then, we extracted 924 radiomic features from each segmented disc in T1 and T2 MRI modalities. All features were processed and selected using minimum redundancy maximum relevance (mRMR) and multiple machine learning algorithms. Meanwhile, the radiomics models of various machine learning algorithms and MRI images were constructed and compared. Finally, the combined radiomics model was constructed in the training set and validated in the test set. Radiomic feature mapping was provided for auxiliary diagnosis.</p><p><bold>Results:</bold> Of the 2,610 cervical disc samples, 794 (30.4%) were classified as low grade and 1,816 (69.6%) were classified as high grade. The fine-tuned MedSAM model achieved good segmentation performance, with the mean Dice coefficient of 0.93. Higher-order texture features contributed to the dominant force in the diagnostic task (80%). Among various machine learning models, random forest performed better than the other algorithms (<italic>p</italic> &lt; 0.01), and the T2 MRI radiomics model showed better results than T1 MRI in the diagnostic performance (<italic>p</italic> &lt; 0.05). The final combined radiomics model had an area under the receiver operating characteristic curve (AUC) of 0.95, an accuracy of 89.51%, a precision of 87.07%, a recall of 98.83%, and an F1 score of 0.93 in the test set, which were all better than those of other models (<italic>p</italic> &lt; 0.05).</p><p><bold>Conclusion:</bold> The radiomics-based decision support tool using T1 and T2 MRI modalities can be used for cervical disc degeneration grading, facilitating individualized management.</p>