AUTHOR=Cabrera Pereira Angel , Dasgupta Krishnakali , Ho Thach-Vu , Pacheco-Vergara Maria , Kim Julie , Kataria Niam , Liang Yaowei , Mei Jeslyn , Yu Jinyeong , Witek Lukasz , Chai Yang , Jeong Juhee TITLE=Lineage-specific mutation of Lmx1b provides new insights into distinct regulation of suture development in different areas of the calvaria JOURNAL=Frontiers in Physiology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1225118 DOI=10.3389/fphys.2023.1225118 ISSN=1664-042X ABSTRACT=
The calvaria (top part of the skull) is made of pieces of bone as well as multiple soft tissue joints called sutures. The latter is crucial to the growth and morphogenesis of the skull, and thus a loss of calvarial sutures can lead to severe congenital defects in humans. During embryogenesis, the calvaria develops from the cranial mesenchyme covering the brain, which contains cells originating from the neural crest and the mesoderm. While the mechanism that patterns the cranial mesenchyme into bone and sutures is not well understood, function of