AUTHOR=Moucaud Blandine , Prince Elodie , Jagla Krzysztof , Soler Cédric 

TITLE=Developmental origin of tendon diversity in Drosophila melanogaster

JOURNAL=Frontiers in Physiology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1176148

DOI=10.3389/fphys.2023.1176148

ISSN=1664-042X

ABSTRACT=<p>Myogenesis is a developmental process that is largely conserved in both <italic>Drosophila</italic> and higher organisms. Consequently, the fruit fly is an excellent <italic>in vivo</italic> model for identifying the genes and mechanisms involved in muscle development. Moreover, there is growing evidence indicating that specific conserved genes and signaling pathways govern the formation of tissues that connect the muscles to the skeleton. In this review, we present an overview of the different stages of tendon development, from the specification of tendon progenitors to the assembly of a stable myotendinous junction across three different myogenic contexts in <italic>Drosophila</italic>: larval, flight and leg muscle development. We underline the different aspects of tendon cell specification and differentiation in embryo and during metamorphosis that result into tendon morphological and functional diversity.</p>