AUTHOR=Caballero Ricardo , Martínez Miguel Ángel , Peña Estefanía 

TITLE=Coronary artery properties in atherosclerosis: A deep learning predictive model

JOURNAL=Frontiers in Physiology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1162436

DOI=10.3389/fphys.2023.1162436

ISSN=1664-042X

ABSTRACT=<p>In this work an Artificial Neural Network (ANN) was developed to help in the diagnosis of plaque vulnerability by predicting the Young modulus of the core (<italic>E</italic><sub><italic>core</italic></sub>) and the plaque (<italic>E</italic><sub><italic>plaque</italic></sub>) of atherosclerotic coronary arteries. A representative <italic>in silico</italic> database was constructed to train the ANN using Finite Element simulations covering the ranges of mechanical properties present in the bibliography. A statistical analysis to pre-process the data and determine the most influential variables was performed to select the inputs of the ANN. The ANN was based on Multilayer Perceptron architecture and trained using the developed database, resulting in a Mean Squared Error (MSE) in the loss function under 10<sup>–7</sup>, enabling accurate predictions on the test dataset for <italic>E</italic><sub><italic>core</italic></sub> and <italic>E</italic><sub><italic>plaque</italic></sub>. Finally, the ANN was applied to estimate the mechanical properties of 10,000 realistic plaques, resulting in relative errors lower than 3%.</p>