AUTHOR=Li Zhiyuan , Dong Shuyan , Huang Shichen , Sun Yuhan , Sun Yingzhi , Zhao Beibei , Qi Qiulan , Xiong Lei , Hong Feng , Jiang Yuxin 

TITLE=Role of CD34 in inflammatory bowel disease

JOURNAL=Frontiers in Physiology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1144980

DOI=10.3389/fphys.2023.1144980

ISSN=1664-042X

ABSTRACT=<p>Inflammatory bowel disease (IBD) is caused by a variety of pathogenic factors, including chronic recurrent inflammation of the ileum, rectum, and colon. Immune cells and adhesion molecules play an important role in the course of the disease, which is actually an autoimmune disease. During IBD, CD34 is involved in mediating the migration of a variety of immune cells (neutrophils, eosinophils, and mast cells) to the inflammatory site, and its interaction with various adhesion molecules is involved in the occurrence and development of IBD. Although the function of CD34 as a partial cell marker is well known, little is known on its role in IBD. Therefore, this article describes the structure and biological function of CD34, as well as on its potential mechanism in the development of IBD.</p>