AUTHOR=Zhang Chaojie , Guo Jia 

TITLE=Diverse functions of the inward-rectifying potassium channel Kir5.1 and its relationship with human diseases

JOURNAL=Frontiers in Physiology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1127893

DOI=10.3389/fphys.2023.1127893

ISSN=1664-042X

ABSTRACT=<p>The inward-rectifying potassium channel subunit Kir5.1, encoded by <italic>Kcnj16</italic>, can form functional heteromeric channels (Kir4.1/5.1 and Kir4.2/5.1) with Kir4.1 (encoded by <italic>Kcnj10</italic>) or Kir4.2 (encoded by <italic>Kcnj15</italic>). It is expressed in the kidneys, pancreas, thyroid, brain, and other organs. Although Kir5.1 cannot form functional homomeric channels in most cases, an increasing number of studies in recent years have found that the functions of this subunit should not be underestimated. Kir5.1 can confer intracellular pH sensitivity to Kir4.1/5.1 channels, which can act as extracellular potassium sensors in the renal distal convoluted tubule segment. This segment plays an important role in maintaining potassium and acid-base balances. This review summarizes the various pathophysiological processes involved in Kir5.1 and the expression changes of Kir5.1 as a differentially expressed gene in various cancers, as well as describing several other disease phenotypes caused by Kir5.1 dysfunction.</p>