AUTHOR=Jiang Li , Wei Wei , Kang Sheng , Li Xiao-Lin , Luo Yu 

TITLE=Insights into lipid metabolism and immune-inflammatory responses in the pathogenesis of coronary artery ectasia

JOURNAL=Frontiers in Physiology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1096991

DOI=10.3389/fphys.2023.1096991

ISSN=1664-042X

ABSTRACT=<p>Coronary artery ectasia (CAE) is a rare finding that is associated with poor clinical outcomes (<xref ref-type="bibr" rid="B21">Kawsara et al. 2018</xref>), and disorders in lipid metabolism have been reported in CAE. Lipids constitute one of the three metabolite types that regulate bodily functions and are also powerful signaling molecules (<xref ref-type="bibr" rid="B20">Han 2016</xref>; <xref ref-type="bibr" rid="B43">Zhu et al. 2021</xref>) that affect immunoregulation and inflammatory responses <italic>via</italic> a series of transcription factors and signaling pathways (<xref ref-type="bibr" rid="B6">Barrera et al. 2013</xref>). Although abnormal lipid metabolism and immunoinflammatory responses have been reported in CAE, their roles in the pathogenic mechanisms underlying CAE are currently unclear.</p>