AUTHOR=Li Kunzhe , Wan Bingzhi , Li Sujuan , Chen Zhixin , Jia Hao , Song Yinping , Zhang Jiamin , Ju Wenyu , Ma Han , Wang Youhua 

TITLE=Mitochondrial dysfunction in cardiovascular disease: Towards exercise regulation of mitochondrial function

JOURNAL=Frontiers in Physiology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1063556

DOI=10.3389/fphys.2023.1063556

ISSN=1664-042X

ABSTRACT=<p>The morbidity and mortality of cardiovascular diseases are exceedingly high worldwide. Pathological heart remodeling, which is developed as a result of mitochondrial dysfunction, could ultimately drive heart failure. More recent research target exercise modulation of mitochondrial dysfunction to improve heart failure. Therefore, finding practical treatment goals and exercise programs to improve cardiovascular disease is instrumental. Better treatment options are available with the recent development of exercise and drug therapy. This paper summarizes pathological states of abnormal mitochondrial function and intervention strategies for exercise therapy.</p>