AUTHOR=Schulte Annemarie , Blum Robert TITLE=Shaped by leaky ER: Homeostatic Ca2+ fluxes JOURNAL=Frontiers in Physiology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.972104 DOI=10.3389/fphys.2022.972104 ISSN=1664-042X ABSTRACT=

At any moment in time, cells coordinate and balance their calcium ion (Ca²⁺) fluxes. The term ‘Ca²⁺ homeostasis’ suggests that balancing resting Ca²⁺ levels is a rather static process. However, direct ER Ca²⁺ imaging shows that resting Ca²⁺ levels are maintained by surprisingly dynamic Ca²⁺ fluxes between the ER Ca²⁺ store, the cytosol, and the extracellular space. The data show that the ER Ca²⁺ leak, continuously fed by the high-energy consuming SERCA, is a fundamental driver of resting Ca²⁺ dynamics. Based on simplistic Ca²⁺ toolkit models, we discuss how the ER Ca²⁺ leak could contribute to evolutionarily conserved Ca²⁺ phenomena such as Ca²⁺ entry, ER Ca²⁺ release, and Ca²⁺ oscillations.