AUTHOR=Xin Haoran , Zhang Jianxin , Huang Rongfeng , Li Lihua , Lam Sin Man , Shui Guanghou , Deng Fang , Zhang Zhihui , Li Min-Dian TITLE=Circadian signatures of adipose tissue in diet-induced obesity JOURNAL=Frontiers in Physiology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.953237 DOI=10.3389/fphys.2022.953237 ISSN=1664-042X ABSTRACT=
High-fat diet (HFD) feeding rewires circadian rhythms of peripheral organs including the liver and adipose tissue. While the liver has been extensively studied, it remains largely unknown whether and how HFD organizes circadian biology in adipose tissue. Here, we took a systems approach to profile the diurnal transcriptome of adipose tissue in diet-induced obese mice either fed a low-fat diet (LFD) that reduces weight or still fed HFD. We detected about 200 and 2,500 diurnal genes in HFD and LFD, respectively. Pathway analysis revealed that rhythmic pathways in HFD are represented by circadian rhythm, ribosome biogenesis, and nucleosome organization, whereas those in LFD are represented by myeloid cell function. Remarkably, the majority of the circadian clock genes, except