AUTHOR=Qin Shuguang , Tian Zhenjun , Boidin Maxime , Buckley Benjamin J. R. , Thijssen Dick H. J. , Lip Gregory Y. H. 

TITLE=Irisin is an Effector Molecule in Exercise Rehabilitation Following Myocardial Infarction (Review)

JOURNAL=Frontiers in Physiology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.935772

DOI=10.3389/fphys.2022.935772

ISSN=1664-042X

ABSTRACT=<p><bold>Background:</bold> Regular exercise is an effective non-pharmacological therapy for treatment and prevention of cardiovascular disease (CVD). The therapeutic benefits of exercise are mediated partly through improved vascular and increase in metabolic health. Release of exercise-responsive myokines, including irisin, is associated with beneficial effects of exercise in CVD patients.</p><p><bold>Observations:</bold> The present review provides an overview of the role of exercise in cardiac rehabilitation of patients with myocardial infarction (MI). Further, the role of irisin as a motion-responsive molecule in improving vascular and metabolic health is explored. Possible mechanism of cardioprotective effect of irisin-mediated exercise on myocardial infarction are also summarized in this review.</p><p><bold>Conclusion and significance of the review:</bold> Irisin is associated with reduced inflammation, antioxidant properties, and anti-apoptotic effect, implying that it is a potential key mediator of the beneficial effects of exercise on vascular and metabolic health. The findings show that irisin is a promising therapeutic target for treatment of patients with cardiovascular disease, particularly post-MI. Further research should be conducted to elucidate the potential mechanisms of cardioprotective effects of irisin and explored whether irisin induced by exercise exerts rehabilitation effects post-MI.</p>