AUTHOR=Zhao Min , Qi Qin , Liu Shimin , Huang Rong , Shen Jiacheng , Zhu Yi , Chai Jing , Zheng Handan , Wu Huangan , Liu Huirong TITLE=MicroRNA-34a: A Novel Therapeutic Target in Fibrosis JOURNAL=Frontiers in Physiology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.895242 DOI=10.3389/fphys.2022.895242 ISSN=1664-042X ABSTRACT=

Fibrosis can occur in many organs, and severe cases leading to organ failure and death. No specific treatment for fibrosis so far. In recent years, microRNA-34a (miR-34a) has been found to play a role in fibrotic diseases. MiR-34a is involved in the apoptosis, autophagy and cellular senescence, also regulates TGF-β1/Smad signal pathway, and negatively regulates the expression of multiple target genes to affect the deposition of extracellular matrix and regulate the process of fibrosis. Some studies have explored the efficacy of miR-34a-targeted therapies for fibrotic diseases. Therefore, miR-34a has specific potential for the treatment of fibrosis. This article reviews the important roles of miR-34a in fibrosis and provides the possibility for miR-34a as a novel therapeutic target in fibrosis.