AUTHOR=Yu James J. , Non Amy L. , Heinrich Erica C. , Gu Wanjun , Alcock Joe , Moya Esteban A. , Lawrence Elijah S. , Tift Michael S. , O'Brien Katie A. , Storz Jay F. , Signore Anthony V. , Khudyakov Jane I. , Milsom William K. , Wilson Sean M. , Beall Cynthia M. , Villafuerte Francisco C. , Stobdan Tsering , Julian Colleen G. , Moore Lorna G. , Fuster Mark M. , Stokes Jennifer A. , Milner Richard , West John B. , Zhang Jiao , Shyy John Y. , Childebayeva Ainash , Vázquez-Medina José Pablo , Pham Luu V. , Mesarwi Omar A. , Hall James E. , Cheviron Zachary A. , Sieker Jeremy , Blood Arlin B. , Yuan Jason X. , Scott Graham R. , Rana Brinda K. , Ponganis Paul J. , Malhotra Atul , Powell Frank L. , Simonson Tatum S. TITLE=Time Domains of Hypoxia Responses and -Omics Insights JOURNAL=Frontiers in Physiology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.885295 DOI=10.3389/fphys.2022.885295 ISSN=1664-042X ABSTRACT=

The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechanisms of hypoxia adaptation and tolerance. Here we synthesize findings across varying time domains of hypoxia in terms of oxygen delivery, ranging from early animal to modern human evolution and examine the potential impacts of environmental and clinical challenges through emerging multi-omics approaches. We discuss how diverse animal species have adapted to hypoxic environments, how humans vary in their responses to hypoxia (i.e., in the context of high-altitude exposure, cardiopulmonary disease, and sleep apnea), and how findings from each of these fields inform the other and lead to promising new directions in basic and clinical hypoxia research.