AUTHOR=Montes-de-Oca-García Adrián , Corral-Pérez Juan , Velázquez-Díaz Daniel , Perez-Bey Alejandro , Rebollo-Ramos María , Marín-Galindo Alberto , Gómez-Gallego Félix , Calderon-Dominguez Maria , Casals Cristina , Ponce-González Jesús G. 

TITLE=Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults

JOURNAL=Frontiers in Physiology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.885185

DOI=10.3389/fphys.2022.885185

ISSN=1664-042X

ABSTRACT=<p>This study aimed to analyze the influence of the peroxisome proliferator-activated receptor (PPAR)-gamma coactivator (PGC)-1 alpha (PPARGC1A) gene rs8192678 C&gt;T polymorphism on different health-related parameters in male and female young adults. The PPARGC1A gene rs8192678 polymorphism was ascertained by polymerase chain reaction in 74 healthy adults (28 women; 22.72 ± 4.40 years) from Andalusia (Spain). Health-related variables included cardiometabolic risk, anthropometry and body composition, biochemical parameters, insulin sensitivity (QUICKI and HOMA-IR indexes), blood pressure (BP) at rest and after exercise, diet, basal metabolism, physical activity, maximal fat oxidation, and cardiorespiratory fitness. Our results showed differences by PPARGC1A gene rs8192678 C&gt;T polymorphism in body mass (<italic>p</italic> = 0.002), body mass index (<italic>p</italic> = 0.024), lean body mass (<italic>p</italic> = 0.024), body fat (<italic>p</italic> = 0.032), waist circumference (<italic>p</italic> = 0.020), and BP recovery ratio (<italic>p</italic> &lt; 0.001). The recessive model (CC vs. CT/TT) showed similar results but also with differences in basal metabolism (<italic>p</italic> = 0.045) and total energy expenditure (<italic>p</italic> = 0.024). A genotype*sex interaction was found in the QUICKI index (<italic>p</italic> = 0.016), with differences between CC and CT/TT in men (<italic>p</italic> = 0.049) and between men and women inside the CT/TT group (<italic>p</italic> = 0.049). Thus, the PPARGC1A gene rs8192678 C&gt;T polymorphism is associated with body composition, basal metabolism, total energy expenditure, and BP recovery, where the CC genotype confers a protective effect. Moreover, our study highlighted sexual dimorphism in the influence of PPARGC1A gene rs8192678 C&gt;T polymorphism on the QUICKI index.</p>