AUTHOR=Yin Haixia , Liang Wenli , Zhao Deshan 

TITLE=The Application Value of the Renal Region of Interest Corrected by Computed Tomography in Single-Kidney Glomerular Filtration Rate for the Evaluation of Patients With Moderate or Severe Hydronephrosis

JOURNAL=Frontiers in Physiology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.861895

DOI=10.3389/fphys.2022.861895

ISSN=1664-042X

ABSTRACT=<p><bold>Objective:</bold> This study aimed to investigate the application value of the renal region of interest (ROI) corrected by computed tomography (CT) in single-kidney glomerular filtration rate (GFR) in patients with hydronephrosis.</p><p><bold>Methods:</bold> A total of 46 patients with hydronephrosis were divided into four groups based on their degree of unilateral hydronephrosis: a normal group (left kidney and right kidney) and three abnormal groups (mild, moderate, and severe hydronephrosis). GFR was measured using the two-sample method (tGFR). The single-kidney GFR of each patient was derived from differential renal function values in dynamic renal imaging multiplied by GFR. The single-kidney GFRs, including GFR from the Gates method (gGFR<sub>single</sub>) and CT area-corrected GFR (aGFR<sub>single</sub>), were compared with tGFR<sub>single</sub>. A paired-sample <italic>t</italic>-test and Pearson’s test were used for data analysis. <italic>p</italic> &lt; 0.05 was considered statistically significant.</p><p><bold>Results:</bold> There were no significant differences between aGFR<sub>single</sub> and tGFR<sub>single</sub> in patients in the normal, mild hydronephrosis, and moderate hydronephrosis groups (<italic>t</italic> = –0.604∼1.982, all <italic>p</italic> &gt; 0.05), but there was a significant difference between them in the severe hydronephrosis group (<italic>t</italic> = 2.302, <italic>p</italic> &lt; 0.05). There were no significant differences between gGFR<sub>single</sub> and tGFR<sub>single</sub> in the normal and mild hydronephrosis groups (<italic>t</italic> = 0.194∼0.962, all <italic>p</italic> &gt; 0.05), but there was a significant difference between them in the moderate and severe hydronephrosis groups (<italic>t</italic> = 3.321, 3.494, <italic>p</italic> &lt; 0.05). Both gGFR<sub>single</sub> and aGFR<sub>single</sub> were correlated with tGFR<sub>single</sub>, with aGFR<sub>single</sub> being more strongly correlated (<italic>r</italic> = 0.890, <italic>p</italic> &lt; 0.001).</p><p><bold>Conclusion:</bold> In patients with moderate hydronephrosis, aGFR<sub>single</sub> is more strongly correlated with tGFR<sub>single</sub> than gGFR<sub>single</sub>. However, in patients with severe hydronephrosis and accompanying renal morphological changes, the aGFR<sub>single</sub> measured by the renal ROI area-correction method using CT has higher accuracy and better clinical application value than the conventional gGFR<sub>single</sub>.</p>