AUTHOR=Bahloul Mohamed A. , Aboelkassem Yasser , Laleg-Kirati Taous-Meriem 

TITLE=Human Hypertension Blood Flow Model Using Fractional Calculus

JOURNAL=Frontiers in Physiology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.838593

DOI=10.3389/fphys.2022.838593

ISSN=1664-042X

ABSTRACT=<p>The blood flow dynamics in human arteries with hypertension disease is modeled using fractional calculus. The mathematical model is constructed using five-element lumped parameter arterial Windkessel representation. Fractional-order capacitors are used to represent the elastic properties of both proximal large arteries and distal small arteries measured from the heart aortic root. The proposed fractional model offers high flexibility in characterizing the arterial complex tree network. The results illustrate the validity of the new model and the physiological interpretability of the fractional differentiation order through a set of validation using human hypertensive patients. In addition, the results show that the fractional-order modeling approach yield a great potential to improve the understanding of the structural and functional changes in the large and small arteries due to hypertension disease.</p>