AUTHOR=Li Rongsong , Xiao Yang , Li Kang , Tian Ling 

TITLE=Transcription and Post-translational Regulation of Autophagy in Insects

JOURNAL=Frontiers in Physiology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.825202

DOI=10.3389/fphys.2022.825202

ISSN=1664-042X

ABSTRACT=<p>Autophagy attracts great attention, and numerous progresses have been obtained in the last two decades. Autophagy is implicated in mammalian neurodegenerative diseases, tumorigenesis, as well as development in insects. The regulatory mechanism of autophagy is well documented in yeast and mammals, whereas it is not fully illustrated in insects. <italic>Drosophila melanogaster</italic> and <italic>Bombyx mori</italic> are the two well-studied insects for autophagy, and several insect-mammalian evolutionarily conserved or insect-specific mechanisms in regulating autophagy are reported. In this review, we summarize the most recent studies of autophagy regulated at both transcriptional and post-translational levels by insect hormone in cooperation with other signals, such as nutrient, which will provide a reference and deep thinking for studies on autophagy in insects.</p>