AUTHOR=Calvillo Laura TITLE=Editorial: 3Rs approach (replace, reduce and refine animal models) to improve preclinical research JOURNAL=Frontiers in Physiology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.1040575 DOI=10.3389/fphys.2022.1040575 ISSN=1664-042X