AUTHOR=Davis Amanda R. , Goodenough Chelsea G. , Westerlind Kim C. , Strange Robert , Deaver John W. , Ryan Patrick J. , Riechman Steven E. , Fluckey James D. 

TITLE=Myokines derived from contracting skeletal muscle suppress anabolism in MCF7 breast cancer cells by inhibiting mTOR

JOURNAL=Frontiers in Physiology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.1033585

DOI=10.3389/fphys.2022.1033585

ISSN=1664-042X

ABSTRACT=<p><bold>Summary:</bold> There is strong evidence that physical activity has a profound protective effect against multiple types of cancer. Here, we show that this effect may be mediated by factors released from skeletal muscle during simulated exercise, <italic>in situ</italic>, which suppress canonical anabolic signaling in breast cancer. We report attenuated growth of MCF7 breast cancer cells in the presence of a rodent-derived exercise conditioned perfusate, independent of prior exercise training. This reduction was concomitant with increased levels of DEPTOR protein and reduced mTOR activity.</p>