Colin G. Scanes- Department of Biological Science, University of Wisconsin Milwaukee, Milwaukee, WI, United States
There has been considerable progress in understanding follicular development, the ovulatory cycle and the oviposition cycles in the hen. In particular, there have been tremendous advances in understanding follicular development and recruitment of follicles to the hierarchy of large yellow follicles. There is a need to continue to follow the earlier literature while employing present techniques. Early work allowed an understanding of the ovulation and oviposition cycles. Models for ovulation were developed. However, while these have no passed the test of time, there is no present model that fully accounts to the cycles. Earlier work employed ahemoral light cycles to examine ovulation and oviposition cycles. Recent work has demonstrated that clock genes are expressed in the ovary. The control of incubation by prolactin has been largely elucidated in turkeys. There is evidence that other endocrine glands influence female reproduction in birds including the adrenal cortex, thyroid and pineal. However, there is much that remains to be fully understood.
Introduction
My interest in the physiology of reproduction in birds dawned with my being a member of the team that developed a radioimmunoassay for chicken luteinizing hormone (LH) (Follett et al., 1972); this being the first assay for a non-mammalian hormone. This and other such assays were used, for instance, to determine changes in plasma concentrations of LH along with progesterone during the ovulatory cycle of chickens (Furr et al., 1973) and the circadian basis of photoperiodic induction of LH release in a wild bird (Follett et al., 1974). Brian Follett went on to an exemplary research career deducing much of the mechanism of photoperiodism in birds.
It is appropriate, 50 years later, to consider what has been learned on the ovulatory or oviposition cycles of chickens and turkeys and what questions remain needing to be addressed. Among the unique features of female reproduction in poultry and other birds are the following:
• A hierarchy of yellow (yolk filled) follicles with a new follicle recruited on a daily basis.
• Ovulation of clutches of eggs with the time of ovulation occurring later in the day as the sequence progresses
• The ovum passing through the oviduct where it acquires albumen (egg white), membranes and a calcareous shell. Once this is complete, the egg is released from the oviduct in the process of oviposition (egg laying). This will not be covered except where is impacts ovulation, oviposition and their timing.
• Broodiness and the incubation of eggs.
Development of follicles
There is a hierarchy of yellow (yolk filled) follicles with follicles increasing in size to a maximum diameter of 2.5 cm due to their filling with yolk. There is also maturation of the granular and thecal cells. The largest follicle will be the first to be ovulated and then the next largest. A new follicle recruited on a daily basis.
Alan Johnson’s laboratory have performed a series of studies on the recruitment and development of the ovarian follicles. Not only does this provide a comprehensive account of follicular development but also the studies themselves were exquisite. The recruitment of small (pre-hierarchal) follicles involves follicle stimulating hormone (FSH) and other factors such as growth factors increasing FSH receptors by granulosa cells from pre-hierarchal follicles. In turn, there are increases in the following:
1) Formation of cyclic adenosine monophosphate (cAMP).
2) Expression of steroidogenic acute regulatory protein (STAR).
3) Production of progesterone by granulosa cells (Kim and Johnson, 2018).
Effects of growth factors include the following:
Bone morphogenetic protein 4 (BMP4) increased expression of the FSH receptor in undifferentiated granulosa cells from pre-hierarchal follicles (Kim et al., 2013). Similarly, (BMP6 increased responsiveness to FSH by granulosa cells from pre-hierarchal follicles (Ocón-Grove et al., 2012). Conversely, BMP2 prevented FSH receptor expression by either transforming growth factor β (TGF β) or FSH by undifferentiated granulosa cells from pre-hierarchal follicles (Haugen and Johnson, 2010).
Transforming growth factor β1 (TGFβ1) increased expression of vascular endothelial growth factor A (VEGF) and its receptor, VEGF receptors (VEGFR) in granulosa cells from prehierarchal follicles (Kim et al., 2016). In turn, VEGF and VEGFR induce angiogenesis and consequently facilitate follicular growth and the deposition of yolk precursors.
BMP6 also increased the expression of anti-Müllerian hormone (AMH) by granulosa cells from pre-hierarchal follicles (Ocón-Grove et al., 2012). In the presence of FSH, BMP4 increased AMH expression by undifferentiated granulosa cells from pre-hierarchal follicle (Kim et al., 2013). Moreover, the effect of BMP4 was blocked in the presence of TGFα or noggin (Kim et al., 2013).
Ovulation and oviposition cycles
For every ovum to be ovulated, there is a surge in circulating concentrations of LH and progesterone. A very few pre-ovulatory surges in circulating concentrations of LH and progesterone were not associated with an egg laid in turkeys (Liu et al., 2001a; Liu et al., 2001b). The interval between LH/progesterone surges is increased late in reproductive period (Liu et al., 2002). A positive feedback loop exists with LH stimulating production of progesterone by granulosa cells particularly those in the largest follicle and progesterone increasing LH release.
Progesterone induces the pre-ovulatory LH surge (Rothchild and Fraps, 1949; Wilson and Sharp, 1975). The effect of progesterone requires the presence of estrogen. Progesterone only provokes a LH surge when ovariectomized hens received estradiol administration of daily prior to challenge (Wilson and Sharp, 1976).
Timing of oviposition and ovulation
The interval between ovipositions is 24–27 h [chickens: (Attwood, 1929) also see Table 1; turkeys: 26.8 h: (Liu et al., 2001a); 26 h: (Brady et al., 2019)]. The interval varies with the length of a sequence in the laying hen (Attwood, 1929) with greater intervals with the shorter sequences (Table 1). Assuming that the interval between oviposition and ovulation of the next ovum in the sequence remains constant at about 30 min (Warren and Scott, 1935), the duration the ovum spends in the oviduct is markedly less in long sequences (Table 1) tending to less 24 h.
TABLE 1. Effect of sequence length on interval between ovipositions [from or calculated from Attwood (1929)].
The interval between oviposition and the next oviposition reflects the time an ovum spends in the oviduct together with the approximately the time between oviposition and the next ovulation (Table 1) [calculated from data in Biellier and Ostmann (1960)]. The interval between ovipositions is greater in short sequences (Table 2) and is longer with long ahemoral light cycles (Table 1) (Morris, 1973; other data calculated from data in Biellier and Ostmann, 1960). With ahemoral light cycles of progressively greater than 24 h, the timing of oviposition is earlier; migrating from during the photophase to the end of the scotophase (calculated from data in Biellier and Ostmann, 1960) (Figure 1; Tables 2, 3). It is unclear how the light/dark cycle influences the duration that an ovum spends in the oviduct?
TABLE 2. Effect of ahemeral light/dark cycles on interval between ovipositions (based on or calculated from data in Biellier and Ostmann, 1960; Morris, 1973).
FIGURE 1. Shifts in the time of oviposition with ahemoral light cycles.
TABLE 3. Effect of ahemeral light/dark cycles on the timing of ovipositions (calculated from data in Biellier and Ostmann, 1960.
In laying hens, ovulation occurs about 30 min following oviposition of the previously ovulated ovum (Warren and Scott, 1935; Melek et al., 1973). There is some difference between the interval oviposition and ovulation irrespective of the photoperiod; this being 24 min for laying hens on a 14L:10D photoperiod and 36 min for hens on ahemeral light schedule (14L:13D) (Melek et al., 1973). What is not clear is the mechanisms for the cross talk between the ovary and oviduct?
The corollary to ovulation occurring 30 min after oviposition of the previous ovum in a sequence is that the surge in circulating concentrations of LH and progesterone occurs about 6 h before oviposition of the previous ovum. What is not clear is how the ovum/pituitary anticipate oviposition of the previous ovum in the sequence? What is the cross talk between the ovary and/or its hypothalamic pituitary control (ovulation) and the oviduct (oviposition of the previously ovulated ovum)?
Laying hens have been selected for reduced intervals between ovipositions under continuous lighting (24L:0D) (Gow et al., 1985). These hens also exhibited reduced intervals between surges in circulating concentrations of LH (Gow et al., 1985). The timing of the surge in circulating concentrations of LH and progesterone occurs at a specific time of day. For instance, in the domestic duck, the first pre-ovulatory surge in circulating concentrations of LH and progesterone in a sequence occurs at the beginning of the scotophase on a 16L:8D photoperiod and 2 h into the scotophase on a 11L:13D photoperiod (Wilson et al., 1982). The first LH surge of a sequence occurs at the beginning of the scotophase in hens on a 14L:10D photoperiod (Johnson and van Tienhoven, 1984). The pre-ovulatory LH surge in chickens occurs at the beginning of the scotophase (Wilson et al., 1985). If the timing of the scotophase is advanced, there is some increase in circulating concentrations of LH, albeit not a full LH surges (Wilson et al., 1985).
Model for the ovulatory cycle
Both oviposition and ovulation occur only during a period of 8–10 h during the day in chickens and turkeys (on a photoperiod of 14L:10D) with the first ovulation in a sequence occurring 8–9 h after the subjective dusk and the last ovulation of a sequence occurring 18–19 h after the subjective dusk. This was called the open-period (Fraps, 1954; Fraps, 1965). The corollary is that the LH/progesterone surge for the first ovulation in a sequence occurs about 3 h into the scotophase. As the sequence progresses, the surge occurs later and later until the last surge occurs 12 h from the subjective dusk. A further corollary is that the LH/progesterone surge is limited to this open period. What was not clear was what was the open period? 1) Was it the ability of the ovary to produce progesterone? There is not evidence for this. 2) Was it the ability of the hypothalamus/pituitary gland to respond to progesterone positive feedback? There is no evidence for this either. Occam’s razor Was it some other mechanism?
An alternate model for the sequence of ovulations postulated two asynchronous cycles with ovulation only occurring when these were synchronized (Bastian and Zarrow, 1955). What was not clear is what was the physiological bases of each cycle? This would seem to be a non-testable hypothesis as the cycles are not defined.
Circadian genes
There are multiple circadian genes. For instance, BMAL1 is heterodimeric transcriptional protein and one of the master genes of the circadian clock (Menet et al., 2014). There is expression of Bmal1 together with other circadian genes in the ovary of the laying hen: cryptochrome circadian regulator (Cry1), Clock and period circadian regulator (Per 2). Moreover, there is evidence that the pre-ovulatory LH surge influences expression of circadian genes (Tischkau et al., 2011; Li et al., 2014). Expression of BMAL1 by chicken follicular granulosa cells has been reported with expression increased by vasoactive intestinal peptide (VIP) (Kim and Johnson, 2016). What are not clear include the following: 1) Are circadian genes expressed in the oviduct? 2) How are circadian genes in the ovary and, potentially also, the oviduct entrained following a shift in photoperiod and under ahemoral cycles? Are they entrained by the light dark cycle or the stage of the sequence and, if so, what is the mechanism of entraining expression of the clock genes? Is the expression of the clock genes influenced by phase advancing or phase delaying the LH/progesterone surge or the imposition of ahemeral lighting cycles?
Neuroendocrine control of female reproduction
A series of papers from J. P. Advis’s laboratory provided evidence for noradrenergic, neuropeptide Y (NPY) and dopaminergic effects on gonadotropin releasing hormone (GnRH) release from the median eminence (Contijoch et al., 1990; Contijoch et al., 1992; Contijoch et al., 1993). Norepinephrine stimulated GnRH release from the median eminence from laying hen (Contijoch et al., 1990). Similarly, neuropeptide Y increased in vitro GnRH release from hen median eminence (Contijoch et al., 1993). Basal GnRH release from the median eminence of hens subjected to feed withdrawal was increased but decreased in the presence of dopamine (Contijoch et al., 1992). Unfortunately, this group did not appear to have continued research on the reproductive physiology of hen. There is further evidence for both dopaminergic and adrenergic control of preovulatory LH surge with the surge blocked in the presence of the dopamine agonist (apomorphine) or an α adrenergic antagonist (phenoxybenzamine) (Knight et al., 1982). What is still unclear whether additional neuropeptides are involved in the control of the pre-ovulatory surge?
Recent progress in dissecting the hypothalami-pituitary—ovarian axis
Gene expression in the hypothalamus, pituitary and ovary was compared between during the pre-ovulatory LH/progesterone in a study of turkey hens in Tom Porters’s laboratory. The changes appear to be not those expected. For instance, there is reduced expression of GnRH in the hypothalamus (Brady et al., 2019). Moreover, there is decreased expression of GnRH receptors and increased expression of GnIH receptors in the pituitary gland (Brady et al., 2019). There was also shifts in expression in the preovulatory surge in the ovary such as decreases in LHR in the granulosa of F1 follicle (Brady et al., 2019). What is not clear is how the role for each component of the hypothalami-pituitary—ovarian axis controlling ovulation?
Broodiness and the incubation of eggs
Our knowledge of the endocrine control of incubation (sitting on eggs) and brooding (care of chicks/poults). Much of this stems for the work of Mohamed El Halawani. Circulating concentrations of prolactin are markedly increased in turkeys during incubation with a decline when the birds are deprived of access to nests (El Halawani et al., 1980). This increase in prolactin is controlled by hypothalamic peptide, vasoactive intestinal peptide (VIP). Immunization of turkeys against VIP prevents the increase in circulating concentrations of prolactin in turkeys (El Halawani et al., 1996; El Halawani et al., 2000). VIP increases prolactin expression and release in turkeys with the effect blocked by dopamine (Sun and El Halawani, 1995; Al Kahtane et al., 2005). Hypothalamic expression of vasoactive intestinal peptides is high in incubating turkeys (Rozenboim et al., 1993). Similarly, there is increased VIP receptor expression in the anterior pituitary glands in turkeys during incubation (Chaiseha et al., 2004). Administration of a dopamine antagonist prevented brooding behavior in poults (Thayananuphat et al., 2011). Unfortunately, Mohamed El Halawai has now retired and is inactive.
Other endocrine inputs
The relationship between adrenal cortical hormones and the ovulation cycle
There is evidence from early studies that adrenal cortical hormones influence can influence ovulation. Ovulation was blocked by administration of the glucocorticoid, dexamethasone, 14 h prior to ovulation (Soliman and Huston, 1974). The effect of dexamethasone was overcome by the administration of adrenocorticotropic hormone (ACTH) (Soliman and Huston, 1974). This is consistent with dexamethasone suppressing adrenocorticotropic hormone (ACTH) release either acting directly at the level of the anterior pituitary gland or indirectly by depressing release of corticotropin releasing hormone and/or the releasing hormones for ACTH, namely arginine vasotocin (AVT) from the hypothalamus. Premature ovulation was induced by the following in order of potency: Deoxycorticosterone, progesterone, and, at very high dose, corticosterone (Etches and Cunningham, 1976). Moreover, each agent induced premature oviposition (Etches and Cunningham, 1976; Wilson and Sharp, 1976). In contrast, ovulation was inhibited by either the synthetic glucocorticoid, dexamethasone (Rzasa et al., 1983) or corticosterone (Williams et al., 1985).
The relationship between thyroid hormones and reproduction
There is evidence for relationships between thyroid hormones and egg laying in poultry with, for instance, plasma concentrations of triiodothyronine decreased during the LH/progesterone surge (Brady et al., 2021). There are decreases in the plasma concentrations of thyroid hormones, triiodothyronine (T3) and thyroxine (T4) prior to the onset of ovulation during sexual maturation (Sechman et al., 2000). Moreover, T3 has been demonstrated to depress plasma concentrations of both LH and estradiol, to induce follicular atresia and to bind to thyroid hormone receptor in ovarian follicles (Sechman et al., 2009; reviewed: Sechman, 2013). What is not clear is whether the shifts in thyroid hormones can be advanced or delayed experimentally?
The relationship between gonadotropin inhibitory hormone and reproduction
The RFamide peptide, gonadotropin inhibitory hormone (GnIH) depresses both release of LH and FSH and expression of the common alpha and FSH beta gonadotrophin subunit in vitro (Ciccone et al., 2004). There are also direct effects of GnIH on the ovary. There is expression of both GnIH and its receptor (GnIHR) in the chicken ovary (Maddineni et al., 2005). Expression of GnIH declines during sexual maturation (Maddineni et al., 2005).
The relationship between melatonin and reproduction
Melatonin administration increased ovarian expression of both melatonin receptors type 1A (MTNR1A) and melatonin receptors type 1B (MTNR1B) (Hao et al., 2020). There have been studies on the effects on light spectrum on ovarian expression of MTNR1A, MTNR1B and melatonin receptors type 1C (MTNR1C) (Li et al., 2015). Expression of MTNR1A and MTNR1C was greater in hens on monochromatic red (660 nm) than green (560 nm) and blue (480 nm) light in small yellow follicles, F5 and F2 follicles (Li et al., 2015). However, there were no effects on ovarian expression of MTNR1B (Li et al., 2015). A role for gonadal receptors melatonin receptors in seasonal breeding has been proposed in starlings (McGuire et al., 2011).
There is a positive correlation between plasma concentration of melatonin and both hypothalamic concentrations of GnIH and GnIHR during reproductive development in chickens (Zhang et al., 2017).
Author contributions
The author confirms being the sole contributor of this work and has approved it for publication.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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Keywords: ovulation cycle, oviposition, follicular development, ahemoral, hen reproduction
Citation: Scanes CG (2022) Discontinuities in understanding follicular development, the ovulatory cycle and the oviposition cycles in the hen: Advances, opportunities, slow downs and complete stops. Front. Physiol. 13:1023528. doi: 10.3389/fphys.2022.1023528
Received: 19 August 2022; Accepted: 12 September 2022;
Published: 03 October 2022.
Edited by:
Paul Siegel, Virginia Tech, United StatesReviewed by:
Andrzej Sechman, University of Agriculture in Krakow, PolandGregoy Y. Bedecarrats, University of Guelph, Canada
Copyright © 2022 Scanes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Colin G. Scanes, cgscanes@icloud.com