AUTHOR=Wang Yucong , Xu Tao , Zhao Hui , Gu Chunxiao , Li Zhongzheng TITLE=Effect of taurine in muscle damage markers and inflammatory cytokines in running exercise JOURNAL=Frontiers in Physiology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.1008060 DOI=10.3389/fphys.2022.1008060 ISSN=1664-042X ABSTRACT=

This study aimed to investigate the effect of taurine on muscle damage markers and inflammatory markers in the running. For that, ten healthy volunteers participated in this study (mean ± SEM; age 24 ± 1 year, body mass 72.2 ± 4.89 kg, height 174.03 ± 2.85 cm, and BMI 23.83 ± 1.27). The running exercise was performed for 5 km, and blood was taken pre-exercise and pre-exercise + tau and post-exercise and post-exercise + tau for biochemical assessment. We assessed serum creatine kinase (CK), CK isoenzyme, Lactate dehydrogenase (LDH), aspartate transaminase (AST), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). CK level was not significantly different in the control and taurine (tau) administrated groups. However, creatine kinase isoenzyme was decreased in the pre-exercise + tau group when compared to the post-exercise + tau group. AST level was increased significantly in the post-exercise compared to the post-exercise + tau group. There was no significant difference observed in the LDH level in both post-exercise and post-exercise + tau. TNF-alpha level was not also significantly different in both post-exercise and post-exercise + tau. However, IL-6 was decreased in the post-exercise + tau when compared to the post-exercise group. In conclusion, we observed that taurine decreases the inflammatory response by decreasing IL-6 and AST, suggesting the role of taurine in regulating inflammatory response could help to increase running performance.