AUTHOR=Lu Yafang , Lu Yaqiong , Meng Jun , Wang Zuo 

TITLE=Pyroptosis and Its Regulation in Diabetic Cardiomyopathy

JOURNAL=Frontiers in Physiology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.791848

DOI=10.3389/fphys.2021.791848

ISSN=1664-042X

ABSTRACT=<p>Diabetic cardiomyopathy (DbCM) is a prevalent disease, characterized by contractile dysfunction and left ventricular hypertrophy. Patients with DbCM have high morbidity and mortality worldwide. Recent studies have identified that pyroptosis, a kind of cell death, could be induced by hyperglycemia involved in the formation of DbCM. This review summarizes the regulatory mechanisms of pyroptosis in DbCM, including NOD-like receptor3, AIM2 inflammasome, long non-coding RNAs, microRNAs, circular RNA, autophagy, and some drugs.</p>