AUTHOR=Han Fengyu , Hu Feng , Wang Tao , Zhou Wei , Zhu Linjuan , Huang Xiao , Bao Huihui , Cheng Xiaoshu 

TITLE=Association Between Basal Metabolic Rate and All-Cause Mortality in a Prospective Cohort of Southern Chinese Adults

JOURNAL=Frontiers in Physiology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.790347

DOI=10.3389/fphys.2021.790347

ISSN=1664-042X

ABSTRACT=<p><bold>Objective:</bold> The aim of this study was to assess the relationship between basal metabolic rate (BMR) and all-cause mortality in southern Chinese adults.</p><p><bold>Methods:</bold> We prospectively examined the relationship between BMR and all-cause mortality in 12,608 Southern Chinese adults with age ≥ 35 years who participated in the National Key R&amp;D Program from 2013–2014 to 2019–2020. Cox proportional hazard models were used to examine the association between BMR and all-cause mortality.</p><p><bold>Results:</bold> A total of 809 deaths (including 478 men and 331 women) occurred during a median follow-up period of 5.60 years. All-cause mortality was higher in elderly individuals than in non-elderly individuals (11.48 vs. 2.04%, <italic>P</italic> &lt; 0.001) and was higher in male subjects than in female subjects (9.84 vs. 4.56%, <italic>P</italic> &lt; 0.001). There was a significantly inverse relationship between BMR levels and all-cause mortality in elderly male individuals (adjusted-HR per SD increase: 0.80, 95% CI: 0.70–0.91, <italic>P</italic> &lt; 0.001). Compared with BMR levels ≤ 1,115 kJ/day, there was lower all-cause mortality in third and highest BMR quartiles in the elderly male subjects (adjusted-HR: 0.71, 95% CI: 0.53–0.95, <italic>P</italic> = 0.022; adjusted-HR: 0.60, 95% CI: 0.43–0.84, <italic>P</italic> = 0.003, respectively).</p><p><bold>Conclusion:</bold> An elevated BMR was independently inversely associated with all-cause mortality in elderly male subjects in a southern Chinese population.</p>