Jian Shi1
María José Cavagnaro
Mingyi Zhao- 1Department of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
- 2Xiangya School of Medicine, Central South University, Changsha, China
- 3College of Medicine-Phoenix, The University of Arizona, Phoenix, AZ, United States
- 4Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
Fractures of complex body parts are often serious and difficult to handle, and they have high technical and training requirements. However, the realistic situation is that there are few opportunities for the junior residents, trainee doctors, and especially medical students to contact enough clinical practice and see such fracture patients. Fortunately, with the rapid development and continuous progress of 3D printing and related technologies, this situation has gradually gotten better and better. In this research, we confirmed that 3D printing technology could improve the effectiveness of fracture teaching and medical learning from multiple dimensions. We comprehensively screened and assessed 223 papers from the Web of Science (WoS) Core Collection on October 3, 2021, with “((3D) AND ((printing) OR (printed)) AND (fracture)) AND ((education) OR (training) OR (teaching))” as the retrieval strategy. Additionally, we used the VOSviewer software to analyze the keywords and countries and the organizations of the publications, then a series of scientometric and visualized analyses were made based on the retrieval results. Afterward, multiple databases were retrieved according to our selection criteria, we selected eight studies for the extensive literature analysis. The extracted data contained information of authors, problems solved, participants, methods, assessments, results, and benefits/limitations. These intuitive and in-depth analyses further confirmed and appraised the advantages of 3D printing in complex fracture models more objectively. In conclusion, 3D printing could improve the effectiveness and extension of fracture teaching, as well as medical learning, by providing the powerful interaction with 3D effect, wakening students learning interest, and allowing the junior residents, trainee doctors to have as realistic a virtual practice experience as possible. Through this research, it is expected that more researchers could be attracted to conduct more comprehensive and thorough studies on the application of 3D printing for training and educational propose, to promote the development of 3D technology-based medical education practice and further deepen the reform of medical education and improve the quality of fracture education and learning.
Introduction
Fracture-associated education is a difficult part of the medical education system. It is a hard task for medical students to understand the fracture-associated basic anatomy and clinical knowledge well only with 2D models such as CT images, X-Ray images, etc. However, common 3D models and cadaveric specimens are usually normal types, and cadaveric specimens are not convenient to use for studying or reviewing all the time. Its rareness also causes limitation, so problems always exist. In recent years, 3D printing technology used in the medical field has become the hotspot, which can create 3D objects through successive deposition of materials in 2D layers. Furthermore, it has been used for surgery simulation, training and making teaching aids, etc. Hence, it is a potential solution for the problems mentioned above (Chae et al., 2015; Baskaran, 2016; Garcia et al., 2018; Oberoi et al., 2018; Pugliese et al., 2018). With the rapid development of 3D technology, more and more 3D printing and medical teaching or learning-related research have emerged. However, little research was carried out for the fundamental literature study about the application of 3D printing and fracture teaching with medical learning. Therefore, accurate evaluation and visualized analysis of relevant publications on the application of 3D printing in fracture education is particularly important.
Comprehensive scientometric assessment, empowered by visual or computational analytical approaches, provides unlimited possibilities to improve the accessibility, reproducibility, correctness, and timeliness of research on a specific category. Scientometric, as well as bibliometrics analysis, are all on the grounds of large-scale literature databases for deeply analyzing, which have become research hotspots and developing trends in lots of different fields (Sugimoto et al., 2019; Kagan et al., 2020; Chen et al., 2021; Shi et al., 2021). In this research, an essential analysis tool, VOSviewer (Van Eck and Waltman, 2017), developed by Nees Jan van Eck and Ludo Waltman at Leiden from Leiden University (Leiden, Netherlands) was used to perform the scientometric assessment and other analysis tasks. The purpose of this research was to select and evaluate current publications and analyze the effects on fracture-associated medical education of 3D printing. We also tried to make clear how efficient it could be when used in medical education. Additionally, after the scientometric assessment and prospect for the future, we hoped to clarify the future development direction of relative research.
Materials and Methods
In this study, we searched the Web of Science (WoS) Core Collection on October 3, 2021, with the following retrieval strategy “((3D) AND ((printing) OR (printed)) AND (fracture)) AND ((education) OR (training) OR (teaching))”. In addition, the time frame was from 2000 to 2020, and we successfully gained 223 publications. Then, we used the VOSviewer software (Leiden, Netherlands), which excellently visualizes abstract concepts, to determine the co-occurrence analysis of all keywords. We also conducted the co-authorship of countries, and the co-author relationship of the organizations was analyzed. Afterward, the abstracts/titles of the outcomes were reviewed, and pieces of research on fracture-associated medical education were selected. Listed below are our selection criteria:
1) The research focuses on the effect of 3D printing on medical education.
2) The research conducted a rigorous comparative analysis experiment.
3) The research has a clear description of the assessment methods.
4) The test subjects of the research are medical undergraduates or residents.
We analyzed the following areas:
1) The problems the research solved.
2) The research participants.
3) The research methods.
4) The assessment methods.
5) The research results.
6) The benefits of 3D printing the research found.
7) The limitations of 3D printing that the research found.
Results
A series of scientometric and visualized analyses were made based on the content retrieved from data sources. All results were summarized as follows: Figure 1A shows the common word network of the most common keywords in the target documents we studied. Research areas include teaching, design, prediction, treatment, and printing technology. In the past two decades, 3D printing has been increasingly linked to fractures. Among all keywords from the publications, 3D printing has the highest frequency and link strength. Besides, additive manufacturing, implants, mechanical properties, and fused deposition modeling also have multifarious to appear in different publications. We found that the articles from China, England, the USA, and Australia were mainly published in recent years while Germany, the Czech Republic, and Serbia have more previously published materials (Figure 1B).
Figure 1. The visualization of keywords and co-author relationship of countries. (A) The co-occurrence network of keywords. (B) The image of the co-author relationship of countries.
We also found that most of the articles were published in China, the USA, South Korea, and England. However, the number of the other developing countries is relatively small. The two most productive countries, namely China and the USA, also have the most active partnership. Their main partners are Germany, England, Australia, and South Korea. Other main contributions to this field are from Russia, the Czech Republic, Canada, France, India, Italy, Japan, and Spain (Figure 2).
Figure 2. Country distribution for the articles.
Figure 3 enlists the journals of the articles in descending order by the impact factor and the average number of citations per paper (2020/5 years). Altogether, 20 journals were included with the leading impact factor of Biomaterials (IF: 12.479). Additionally, the distribution of selected per year was shown in Figure 4 while the number of publications issued by institutions and the density of co-author relationships were shown in Figure 5. We could clearly see the apparent upward trend of publications number year by year. Among all the organizations or institutions, Shanghai Jiao Tong University (China) and University of Sydney (Australia) are led by 6 publications. Other main contributions to this field are also from the University of Birmingham (England), Fudan University (China), and Sichuan University (China).
Figure 3. Impact factors and journal publication frequency.
Figure 4. Year distribution of the selected articles.
Figure 5. Visualization of number of publications issued by institutions and the density of co-author relationship.
Afterward, we reviewed the titles and abstracts, excluding duplicates and getting a full text from multiple databases were retrieved according to our selection criteria, and eight studies were selected for the extensive literature analysis. The extracted data contained information of authors, problems solved, participants, methods, assessments, results, and benefits/limitations. In the screening process, non-medical or non-biological and veterinary-related publications were also not selected. Table 1 shows the comprehensive summaries of the selected studies (Li et al., 2015; Cao et al., 2017; Chuang et al., 2017; Huang et al., 2018; Lim et al., 2018; Meng et al., 2018; Wu et al., 2018; Tan et al., 2019).
Table 1. Summary table of published studies utilizing bone fracture with an assessment of the 3D printing.
Discussion
Understanding the knowledge of fractures, especially of the complex structures, appropriately is a fundamental educational component but a difficult point for medical students and residents. Several complex parts of bony anatomy structure such as acetabulum and spine cause it hard for students learning with only 2D images to fully understand the morphological characteristics of relative fracture or create three-dimensional concepts in their mind. And cadaveric specimens are scarce and usually normal types without fracture for students to study (Liu et al., 2020). Similarly, the conventional physical models which can be mass-produced are also normal types. So, there are several limitations in conventional teaching methods of fracture teaching and learning.
Three-dimensional (3D) printing is a potential solution for those problems, with the ability to build specified and highly accurate 3D models quickly (Baskaran, 2016; Garcia et al., 2018) Therefore, 3D printing has special advantages in fracture-associated education and training. Its use in medical education is gradually becoming a hot spot in recent years and there have been many pieces of research in this field already. However, rigorous experimental studies are still scarce in this area, most studies remain subjective and qualitative. Teachers can prepare patient-specific models according to their needs, making the procedure of teaching more flexible and diverse.
All of the eight publications we reviewed had demonstrated that 3D printing improves the learning outcomes in education of one kind or several kinds of fractures significantly, for medical students or residents. Compared to the conventional teaching method, the most significant benefit of using 3D printed models is that it is closest to the real situation. From this perspective, it can be seen as the substitute for cadaveric specimens, which are too precious and rare to use for training usually. Lim et al. (2018) used 15 station testing to objectively evaluate the influence of XR, CT, and 3D printing on residents' judgment of acetabulum fracture classification and conducted a questionnaire survey of residents participating in the experiment. Interestingly, in the questionnaire survey, there are slightly more people who think that 3D printing is sufficient to help determine the type of fracture than those who think that CT is enough to help determine the type of fracture, but in the objective testing results, there was no significant difference in the odds ratio between CT vs. 3D models groups. At the same time, it is generally believed among the respondents that 3D printing has increased their confidence in identifying the type of fracture. This may be a psychological effect that participants think 3D printing can bring some improvement to the recognition success because the 3D model is closer to the real situation. The classification of acetabular fractures using CT or 3D printing has similar effects. Certainly, the residents may be more exposed to CT during previous learning and training. Perhaps with the same experience of using CT or 3D models, 3D printing will indeed improve the recognition success, which needs further experimental verification. The research of Wu et al. (2018) has given us a major inspiration that 3D printing has different effects on the teaching of anatomy in different parts. In some simple parts such as the upper and lower limbs, the two-dimensional teaching with CT is enough to meet the needs of undergraduates. 3D printing did not bring significant improvement. But for more complex parts such as the pelvis and spine, 3D printing models were demonstrated to make sense in improving teaching effects. The higher scores and shorter completion time tell us that 3D printing has brought undergraduates a better understanding of complex bones. Therefore, in the future, similar larger-scale and systematic teaching experiments on more parts should be conducted to make clear which part of the teaching can be improved by 3D printing. The multi-center research conducted by Huang et al. (2018) has high credibility. The authors have compared the teaching effects of ordinary models, virtual reality (VR) virtual models, and 3D models. The objective results show that 3D models and VR models are superior to ordinary models in many aspects. And 3D is the best choice among the three in more aspects; subjective survey results show that students have more interest in learning with 3D printing and VR models. Therefore, 3D printed model is considered the most valuable learning material for understanding acetabular fractures. VR is similar to 3D printing in terms of visualization but does not have the characteristics of 3D printing in terms of tangibility, this may cause the difference between the two leading methods. Similar research has been conducted by Li et al. (2015) who Compare the teaching effect of CT, 3D image, and 3D model, using subjective and objective assessment methods. Both two aspects of the assessment show that both 3D images and 3D models are better choices. Interestingly, although there is no difference in the objective outcomes in the 3D image and 3D group, in the 3D image group, males perform better than females, which did not appear in the 3D group. In addition to showing that men may be better than women in spatial awareness, this result also tells us that 3D models are more suitable for application and teaching to improve the performance of both men and women as much as possible is a better choice when compared to VR or 3D images.
We noticed that all of the subjective survey outcomes are very positive, telling us 3D printing brings confidence and interest in a relative educational procedure to the students, which is a promoter for teaching and learning. 3D printing not only prevails other teaching methods objectively but also plays a very positive role in changing the subjective attitude of students to learning. In a word, 3D printing can be regarded as the most ideal teaching aid among available ones now.
Conclusion
During the scientometric assessment and the extensive literature analysis, we noticed the great power of 3D printing using in fracture-associated medical education. It reveals the application of 3D printing for fracture education and we can realize that it has an excellent promotion effect for medical beginners to learn fractures, especially the complex sites. Compared to traditional teaching methods, 3D printing affords better tactile feedback, which is the reason why 3D printing is more popular with students. Besides, in the subjective questionnaire survey, it was found that 3D printing has a higher mean score of satisfaction. Therefore, we believe that 3D printing models should be more widely used in the basic teaching of fractures.
However, when learning normal bone structure, ordinary bone models are sufficient for daily teaching, and there is no need to use relatively expensive 3D printing. As for the relatively less complex bone sites (upper limb and lower limb), the teaching effect brought by 3D printing is not so significant, using 2D CT images (or 3D reconstruction images is enough to achieve high-level teaching effects at low cost. Furthermore, what kind of material is used for 3D printing is also exceedingly important. Today the printing materials are mainly biological, organic, and inorganic materials. The current 3D printing model can replicate the original shape perfectly, but still needs improvement in terms of feel and strength. Using the 3D printed models, we may get better tactile feedback in the future.
We hope that in the future, there will be much more relative rigorous educational trials conducted to make clear the feasibility and necessity of using 3D printing in various teaching scenarios and that 3D printing continues to further improve clinic performance of doctors and medical education from several perspectives.
Data Availability Statement
The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author/s.
Author Contributions
JS and SX collected the literature and drafted the initial manuscript. SF assisted in the preparation of the figures and table. MC revised the manuscript and edited the language. MZ was the lead investigator. JS, SF, MC, SX, and MZ contributed to the study's conception and design. All authors approved the final manuscript as submitted and are accountable for all aspects of the work.
Funding
This work was supported by the Excellent Postdoctoral Program for Innovative Talent of Hunan (2020RC2015), the China Postdoctoral Science Foundation (2020TQ0364) and the Natural Science Foundation of Hunan (2020JJ5865).
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's Note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Acknowledgments
We thank all the publications and their authors involved in this study. We would like to dedicate this study to Tumen (1960-2021) and Stephen Sondheim (1930-2021).
References
Baskaran, V, Štrkalj, G, Štrkalj, M, and Di Ieva, A. (2016). Current applications and future perspectives of the use of 3D printing in anatomical training and neurosurgery. Front. Neuroanat. 10, 69. doi: 10.3389/fnana.2016.00069
Cao, B., Ma, C., Cheng, X. C., Alimujiang, A., Ren, P., Tang, D. D., et al. (2017). Chinese Journal of Bone and Joint. 6, 345–347. doi: 10.3969/j.issn.2095-252X.2017.05.005
Chae, M. P., Rozen, W. M., McMenamin, P. G., Findlay, M. W., Spychal, R. T., and Hunter-Smith, D. J. (2015). Emerging applications of bedside 3D printing in plastic surgery. Front. Surg. 2, 25. doi: 10.3389/fsurg.2015.00025
Chen, H., Li, R., Zhang, F., Yao, Q., and Guo, Y. (2021). A scientometric visualization analysis for natural products on cancer research from 2008 to 2020. Front. Pharmacol. 14:e0223994. doi: 10.3389/fphar.2021.650141
Chuang, M., Xinchun, C., and Aihemaitijiang, Y. (2017). Application of 3D print model in the teaching of limbs fracture. J. Cardiovasc. Surg. 6, 258–260.
Garcia, J., Yang, Z., Mongrain, R., Leask, R. L., and Lachapelle, K. (2018). 3D printing materials and their use in medical education: a review of current technology and trends for the future. BMJ Simulat. Technol. Enhan. Learn. 4, 27–40. doi: 10.1136/bmjstel-2017-000234
Huang, Z., Song, W., Zhang, Y., Zhang, Q., Zhou, D., Zhou, X., et al. (2018). Three-dimensional printing model improves morphological understanding in acetabular fracture learning: A multicenter, randomized, controlled study. PLoS ONE. 13, e0191328. doi: 10.1371/journal.pone.0191328
Kagan, D., Moran-Gilad, J., and Fire, M. (2020). Scientometric trends for coronaviruses and other emerging viral infections. GigaScience. 9, giaa085. doi: 10.1093/gigascience/giaa085
Li, Z., Li, Z., Xu, R., Li, M., Li, J., Liu, Y., et al. (2015). Three-dimensional printing models improve understanding of spinal fracture—A randomized controlled study in China. Sci. Rep. 5, 11570. doi: 10.1038/srep11570
Lim, P. K., Stephenson, G. S., Keown, T. W., Byrne, C., Lin, C. C., Marecek, G. S., et al. (2018). Use of 3D printed models in resident education for the classification of acetabulum fractures. J. Surg. Educ. 75, 1679–1684. doi: 10.1016/j.jsurg.2018.04.019
Liu, K., Ma, L. i. Z., and Lian, Y. H. (2020). 3D-printed pelvis model is an efficient method of osteotomy simulation for the treatment of developmental dysplasia of the hip. Exper. Therap. Med. 19, 1155–1160. doi: 10.3892/etm.2019.8332
Meng, D., Chen, Y., Lin, H. D., Ouyang, Y. P., and Zhao, L. Y. (2018). Application of 3D Printing Technology in the Clinical Teaching of Complex Articular Fracture. Med Inf. 31, 26–28. doi: 10.3969/j.issn.1006-1959.2018.23.008
Oberoi, G., Nitsch, S., Edelmayer, M., Janjić, K., Müller, A. S., and Agis, H. (2018). 3D Printing—encompassing the facets of dentistry. Front. Bioeng. Biotechnol. 6, 172. doi: 10.3389/fbioe.2018.00172
Pugliese, L., Marconi, S., Negrello, E., Mauri, V., Peri, A., Gallo, V., et al. (2018). The clinical use of 3D printing in surgery. Updat. Surg. 70, 381–388. doi: 10.1007/s13304-018-0586-5
Shi, J., Du, X., Cavagnaro, M. J., and Li, N. (2021). A bibliometric analysis and visualization of the top-cited publications in mild traumatic brain injury. Front. Neurol. 12. doi: 10.3389/fneur.2021.687796
Sugimoto, C. R., Ahn, Y. Y., Smith, E., Macaluso, B., and Larivière, V. (2019). Factors affecting sex-related reporting in medical research: a cross-disciplinary bibliometric analysis. Lancet. 393, 550–559. doi: 10.1016/S0140-6736(18)32995-7
Tan, H. T., Wei, B. S., Li, MW, Lu, D, and Luo, X. (2019). Application of 3D Printing Technology in the Teaching of Condylar Fracture. China Contin. Med. Educ. 11, 22–25. doi: 10.3969/j.issn.1674-9308.2019.27.010
Van Eck, N. J., and Waltman, L. (2017). Citation-based clustering of publications using CitNetExplorer and VOSviewer. Scientometrics. 111, 1053–1070. doi: 10.1007/s11192-017-2300-7
Wu, A.M., Wang, K., Wang, J.S., Chen, C.H., Yang, X.D., Ni, W.F., et al. (2018). The addition of 3D printed models to enhance the teaching and learning of bone spatial anatomy and fractures for undergraduate students: a randomized controlled study. Ann. Transl. Med. 6, 403. doi: 10.21037/atm.2018.09.59
Keywords: 3D printing, teaching and learning, fracture, multidisciplinary cooperation, scientometric, advanced medical education
Citation: Shi J, Fu S, Cavagnaro MJ, Xu S and Zhao M (2021) 3D Printing Improve the Effectiveness of Fracture Teaching and Medical Learning: A Comprehensive Scientometric Assessment and Future Perspectives. Front. Physiol. 12:726591. doi: 10.3389/fphys.2021.726591
Received: 17 June 2021; Accepted: 30 November 2021;
Published: 24 December 2021.
Edited by:
Thorsten M. Buzug, University of Lübeck, GermanyReviewed by:
Fanglin Guan, Xi'an Jiaotong University Health Science Center, ChinaTomasz Lekszycki, Warsaw University of Technology, Poland
Natalina Quarto, Stanford University, United States
Copyright © 2021 Shi, Fu, Cavagnaro, Xu and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Shaokang Xu, ODMwMTE5MDMwOSYjeDAwMDQwO2NzdS5lZHUuY24=; Mingyi Zhao, emhhb19taW5neWkmI3gwMDA0MDtjc3UuZWR1LmNu