AUTHOR=Sauerbruch Tilman , Hennenberg Martin , Trebicka Jonel , Beuers Ulrich TITLE=Bile Acids, Liver Cirrhosis, and Extrahepatic Vascular Dysfunction JOURNAL=Frontiers in Physiology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.718783 DOI=10.3389/fphys.2021.718783 ISSN=1664-042X ABSTRACT=
The bile acid pool with its individual bile acids (BA) is modulated in the enterohepatic circulation by the liver as the primary site of synthesis, the motility of the gallbladder and of the intestinal tract, as well as by bacterial enzymes in the intestine. The nuclear receptor farnesoid X receptor (FXR) and Gpbar1 (TGR5) are important set screws in this process. Bile acids have a vasodilatory effect, at least according to