AUTHOR=Cetin-Atalay Rengul , Meliton Angelo Y. , Wu David , Woods Parker S. , Sun Kaitlyn A. , Peng Ying-Jie , Nanduri Jayasri , Su Xiaoyu , Fang Yun , Hamanaka Robert B. , Prabhakar Nanduri , Mutlu Gökhan M. TITLE=Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release JOURNAL=Frontiers in Physiology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.701995 DOI=10.3389/fphys.2021.701995 ISSN=1664-042X ABSTRACT=
Obstructive sleep apnea (OSA) is a common breathing disorder affecting a significant percentage of the adult population. OSA is an independent risk factor for cardiovascular disease (CVD); however, the underlying mechanisms are not completely understood. Since the severity of hypoxia correlates with some of the cardiovascular effects, intermittent hypoxia (IH) is thought to be one of the mechanisms by which OSA may cause CVD. Here, we investigated the effect of IH on endothelial cell (EC) activation, characterized by the expression of inflammatory genes, that is known to play an important role in the pathogenesis of CVD. Exposure of C57BL/6 mice to IH led to aortic EC activation, while