AUTHOR=Rankovic Marina , Draginic Nevena , Jeremic Jovana , Samanovic Andjela Milojevic , Stojkov Svetlana , Mitrovic Slobodanka , Jeremic Nevena , Radonjic Tanja , Srejovic Ivan , Bolevich Sergey , Svistunov Andrey , Jakovljevic Vladimir , Turnic Tamara Nikolic TITLE=Protective Role of Vitamin B1 in Doxorubicin-Induced Cardiotoxicity in Rats: Focus on Hemodynamic, Redox, and Apoptotic Markers in Heart JOURNAL=Frontiers in Physiology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.690619 DOI=10.3389/fphys.2021.690619 ISSN=1664-042X ABSTRACT=
Up until now, the specific mechanisms involved in doxorubicin (DOX)-induced cardiotoxicity have not been fully elucidated. Since thiamine deficiency is associated with myocardial dysfunction and it may lead to cardiomyopathy, we aimed to investigate whether thiamine (Vitamin B1) treatment provides cardioprotection and modulates DOX mediated subchronic cardiotoxicity as well as to determine possible mechanisms of its effects. The study involved 48 Wistar albino rats divided into four groups: healthy non-treated rats and healthy rats treated with thiamine and DOX rats without treatment and DOX rats treated with thiamine. DOX was applied as a single i.p.injection (15mg/kg), while thiamine treatment lasted 7days (25mg/kg/dayi.p.). Before and after the treatment hemodynamic changes were monitored