AUTHOR=Axsom Jessie E. , Schmidt Heath D. , Matura Lea Ann , Libonati Joseph R. 

TITLE=The Influence of Epigenetic Modifications on Metabolic Changes in White Adipose Tissue and Liver and Their Potential Impact in Exercise

JOURNAL=Frontiers in Physiology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.686270

DOI=10.3389/fphys.2021.686270

ISSN=1664-042X

ABSTRACT=<p><bold>Background:</bold> Epigenetic marks are responsive to a wide variety of environmental stimuli and serve as important mediators for gene transcription. A number of chromatin modifying enzymes orchestrate epigenetic responses to environmental stimuli, with a growing body of research examining how changes in metabolic substrates or co-factors alter epigenetic modifications.</p><p><bold>Scope of Review:</bold> Here, we provide a systematic review of existing evidence of metabolism-related epigenetic changes in white adipose tissue (WAT) and the liver and generate secondary hypotheses on how exercise may impact metabolism-related epigenetic marks in these tissues.</p><p><bold>Major Conclusions:</bold> Epigenetic changes contribute to the complex transcriptional responses associated with WAT lipolysis, hepatic <italic>de novo</italic> lipogenesis, and hepatic gluconeogenesis. While these metabolic responses may hypothetically be altered with acute and chronic exercise, direct testing is needed.</p>