AUTHOR=Ubaida-Mohien Ceereena , Moaddel Ruin , Moore Ann Zenobia , Kuo Pei-Lun , Faghri Faraz , Tharakan Ravi , Tanaka Toshiko , Nalls Mike A. , Ferrucci Luigi TITLE=Proteomics and Epidemiological Models of Human Aging JOURNAL=Frontiers in Physiology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.674013 DOI=10.3389/fphys.2021.674013 ISSN=1664-042X ABSTRACT=

Human aging is associated with a decline of physical and cognitive function and high susceptibility to chronic diseases, which is influenced by genetics, epigenetics, environmental, and socio-economic status. In order to identify the factors that modulate the aging process, established measures of aging mechanisms are required, that are both robust and feasible in humans. It is also necessary to connect these measures to the phenotypes of aging and their functional consequences. In this review, we focus on how this has been addressed from an epidemiologic perspective using proteomics. The key aspects of epidemiological models of aging can be incorporated into proteomics and other omics which can provide critical detailed information on the molecular and biological processes that change with age, thus unveiling underlying mechanisms that drive multiple chronic conditions and frailty, and ideally facilitating the identification of new effective approaches for prevention and treatment.