AUTHOR=Lu Tyler M. , Barcia Durán José Gabriel , Houghton Sean , Rafii Shahin , Redmond David , Lis Raphaël TITLE=Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells: Current Controversies JOURNAL=Frontiers in Physiology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.642812 DOI=10.3389/fphys.2021.642812 ISSN=1664-042X ABSTRACT=
Brain microvascular endothelial cells (BMECs) possess unique properties that are crucial for many functions of the blood-brain-barrier (BBB) including maintenance of brain homeostasis and regulation of interactions between the brain and immune system. The generation of a pure population of putative brain microvascular endothelial cells from human pluripotent stem cell sources (iBMECs) has been described to meet the need for reliable and reproducible brain endothelial cells