AUTHOR=Natarajan Gayathri K. , Mishra Jyotsna , Camara Amadou K. S. , Kwok Wai-Meng 

TITLE=LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling

JOURNAL=Frontiers in Physiology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.637852

DOI=10.3389/fphys.2021.637852

ISSN=1664-042X

ABSTRACT=<p>Nearly 2 decades since its discovery as one of the genes responsible for the Wolf-Hirschhorn Syndrome (WHS), the primary function of the leucine-zipper EF-hand containing transmembrane 1 (LETM1) protein in the inner mitochondrial membrane (IMM) or the mechanism by which it regulates mitochondrial Ca<sup>2+</sup> handling is unresolved. Meanwhile, LETM1 has been associated with the regulation of fundamental cellular processes, such as development, cellular respiration and metabolism, and apoptosis. This mini-review summarizes the diversity of cellular functions impacted by LETM1 and highlights the multiple roles of LETM1 in health and disease.</p>