AUTHOR=Rovina Rafael L. , da Rocha Alisson L. , Marafon Bruno B. , Pauli José R. , de Moura Leandro P. , Cintra Dennys E. , Ropelle Eduardo R. , da Silva Adelino S. R. 

TITLE=One Bout of Aerobic Exercise Can Enhance the Expression of Nr1d1 in Oxidative Skeletal Muscle Samples

JOURNAL=Frontiers in Physiology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.626096

DOI=10.3389/fphys.2021.626096

ISSN=1664-042X

ABSTRACT=<p>The nuclear receptor subfamily 1, group D member 1 (<italic>Nr1d1)</italic>, plays a role in the skeletal muscle’s oxidative capacity, mitochondrial biogenesis, atrophy genes, and muscle fiber size. In light of the effects of physical exercise, the present study investigates the acute response of <italic>Nr1d1</italic> and genes related to atrophy and mitochondrial biogenesis on endurance and resistance exercise protocols. In this investigation, we observed, after one bout of endurance exercise, an upregulation of <italic>Nr1d1</italic> in soleus muscle, but not in the gastrocnemius, and some genes related to mitochondrial biogenesis and atrophy were enhanced as well. Also, analysis of muscle transcripts from diverse isogenic BXD mice families revealed that the strains with higher <italic>Nr1d1</italic> gene expression displayed upregulation of AMPK signaling and mitochondrial-related genes. In summary, a single session of endurance exercise can enhance the <italic>Nr1d1</italic> mRNA levels in an oxidative muscle.</p>