AUTHOR=Bar Stéphane , Nguyen Maxime , Abou-Arab Osama , Dupont Hervé , Bouhemad Belaid , Guinot Pierre-Grégoire TITLE=Dynamic Arterial Elastance Is Associated With the Vascular Waterfall in Patients Treated With Norepinephrine: An Observational Study JOURNAL=Frontiers in Physiology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.583370 DOI=10.3389/fphys.2021.583370 ISSN=1664-042X ABSTRACT=

Introduction: It has been suggested that dynamic arterial elastance (Ea_dyn) can predict decreases in arterial pressure in response to changing norepinephrine levels. The objective of this study was to determine whether Ea_dyn is correlated with determinants of the vascular waterfall [critical closing pressure (CCP) and systemic arterial resistance (SARi)] in patients treated with norepinephrine.

Materials and Methods: Patients treated with norepinephrine for vasoplegia following cardiac surgery were studied. Vascular and flow parameters were recorded immediately before the norepinephrine infusion and then again once hemodynamic parameters had been stable for 15 min. The primary outcomes were Ea_dyn and its associations with CCP and SARi. The secondary outcomes were the associations between Ea_dyn and vascular/flow parameters.

Results: At baseline, all patients were hypotensive with Ea_dyn of 0.93 [0.47;1.27]. Norepinephrine increased the arterial blood pressure, cardiac index, CCP, total peripheral resistance (TPRi), arterial elastance, and ventricular elastance and decreased Ea_dyn [0.40 (0.30;0.60)] and SARi. Ea_dyn was significantly associated with arterial compliance (C_A), CCP, and TPRi (p < 0.05).

Conclusion: In patients with vasoplegic syndrome, Ea_dyn was correlated with determinants of the vascular waterfall. Ea_dyn is an easy-to-read functional index of arterial load that can be used to assess the patient’s macro/microcirculatory status.

Clinical Trial Registration:ClinicalTrials.gov #NCT03478709.