AUTHOR=Benissan-Messan Dathe Z. , Zhu Hua , Zhong Weina , Tan Tao , Ma Jianjie , Lee Peter H. U. 

TITLE=Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration

JOURNAL=Frontiers in Physiology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2020.583393

DOI=10.3389/fphys.2020.583393

ISSN=1664-042X

ABSTRACT=<p>Since its identification in 2009, multiple studies have indicated the importance of MG53 in muscle physiology. The protein is produced in striated muscles but has physiologic implications reaching beyond the confines of striated muscles. Roles in muscle regeneration, calcium homeostasis, excitation-contraction coupling, myogenesis, and the mitochondria highlight the protein’s wide-reaching impact. Numerous therapeutic applications could potentially emerge from these physiologic roles. This review summarizes the current literature regarding the role of MG53 in the skeletal muscle. Therapeutic applications are discussed.</p>