AUTHOR=Henning Stumpf Bernd , Ambriović-Ristov Andreja , Radenovic Aleksandra , Smith Ana-Sunčana TITLE=Recent Advances and Prospects in the Research of Nascent Adhesions JOURNAL=Frontiers in Physiology VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2020.574371 DOI=10.3389/fphys.2020.574371 ISSN=1664-042X ABSTRACT=

Nascent adhesions are submicron transient structures promoting the early adhesion of cells to the extracellular matrix. Nascent adhesions typically consist of several tens of integrins, and serve as platforms for the recruitment and activation of proteins to build mature focal adhesions. They are also associated with early stage signaling and the mechanoresponse. Despite their crucial role in sampling the local extracellular matrix, very little is known about the mechanism of their formation. Consequently, there is a strong scientific activity focused on elucidating the physical and biochemical foundation of their development and function. Precisely the results of this effort will be summarized in this article.